TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

• Published in: The Journal of clinical investigation Vol. 132; no. 19; pp. 1 - 16
• Main Authors: Xie, Di, Stutz, Bernardo, Li, Feng, Chen, Fan, Lv, Haining, Sestan-Pesa, Matija, Catarino, Jonatas, Gu, Jianlei, Zhao, Hongyu, Stoddard, Christopher E., Carmichael, Gordon G., Shanabrough, Marya, Taylor, Hugh S., Liu, Zhong-Wu, Gao, Xiao-Bing, Horvath, Tamas L., Huang, Yingqun
• Format: Journal Article
• Language: English
• Published: Ann Arbor American Society for Clinical Investigation 01.10.2022
• Subjects: Ablation; Analysis; Animal models; Appetite; Bioenergetics; Biomedical research; Cell culture; Chromatin; CRISPR; Demethylation; Diabetes; Diabetes mellitus; Drinking water; Energy; Energy expenditure; Energy metabolism; Epigenetics; Feeding behavior; Food intake; Gene expression; Gene regulation; Health aspects; Homeostasis; Hyperphagia; Hypothalamus; Leptin; Metabolism; Neurons; Neuropeptide Y; Neuropeptides; Neuroscience; Obesity; Peptides; Proteins; Rodents; Stress (Physiology); Stress response; γ-Aminobutyric acid; United States

The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide-expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also modulating nonfeeding behaviors. Besides AGRP, thes...