Transcription of follicle-stimulating hormone subunit genes is modulated by porcine LIM homeobox transcription factors, LHX2 and LHX3

• Published in: Journal of Reproduction and Development Vol. 62; no. 3; pp. 241 - 248
• Main Authors: YOSHIDA, Saishu, KATO, Takako, NISHIMURA, Naoto, KANNO, Naoko, CHEN, Mo, UEHARU, Hiroki, NISHIHARA, Hiroto, KATO, Yukio
• Format: Journal Article
• Language: English
• Published: Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 2016; The Society for Reproduction and Development
• Subjects: Animals; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cricetulus; Deoxyribonuclease I - metabolism; Follicle Stimulating Hormone, beta Subunit - genetics; Follicle Stimulating Hormone, beta Subunit - metabolism; Gene regulation; Glycoprotein hormone; Glycoprotein Hormones, alpha Subunit - genetics; Glycoprotein Hormones, alpha Subunit - metabolism; Immunohistochemistry; LHX2; LHX3; LIM-homeodomain; LIM-Homeodomain Proteins - metabolism; Mice; Original; Pituitary; Pituitary Gland - metabolism; Promoter Regions, Genetic; Protein Domains; Swine; Transcription Factors - metabolism; Transcription, Genetic

The LIM-homeobox transcription factors LHX2 and LHX3s (LHX3a and LHX3b) are thought to be involved in regulating the pituitary glycoprotein hormone subunit genes Cga and Fshβ. These two factors show considerable differences in their amino acid sequences for DNA binding and protein-protein interactio...