microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33 −/− mice are unable to m...

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Published inNature communications Vol. 12; no. 1; pp. 843 - 17
Main Authors Horie, Takahiro, Nakao, Tetsushi, Miyasaka, Yui, Nishino, Tomohiro, Matsumura, Shigenobu, Nakazeki, Fumiko, Ide, Yuya, Kimura, Masahiro, Tsuji, Shuhei, Rodriguez, Randolph Ruiz, Watanabe, Toshimitsu, Yamasaki, Tomohiro, Xu, Sijia, Otani, Chiharu, Miyagawa, Sawa, Matsushita, Kazuki, Sowa, Naoya, Omori, Aoi, Tanaka, Jin, Nishimura, Chika, Nishiga, Masataka, Kuwabara, Yasuhide, Baba, Osamu, Watanabe, Shin, Nishi, Hitoo, Nakashima, Yasuhiro, Picciotto, Marina R., Inoue, Haruhisa, Watanabe, Dai, Nakamura, Kazuhiro, Sasaki, Tsutomu, Kimura, Takeshi, Ono, Koh
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.02.2021
Nature Publishing Group
Nature Portfolio
Subjects
45/41
64/60
692/308/1426
692/699/317
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - physiology
Animals
Body temperature
Body Temperature - physiology
Body Weight
Brain
Brain - metabolism
Cell Line
Circuits
Cold
Cold Temperature
Diet, High-Fat
Dopamine
Dopamine β-monooxygenase
Endoplasmic Reticulum Stress
Energy balance
Gene dosage
Genes
Humanities and Social Sciences
Humans
Hydroxylase
Hypothalamus
Integrases - metabolism
Maintenance
Male
Mice
Mice, Obese
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
multidisciplinary
Neurotransmission
Oxygen Consumption - physiology
Phenotype
Protein Subunits - genetics
Protein Subunits - metabolism
Receptors
Receptors, GABA-A - genetics
Receptors, GABA-A - metabolism
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Sympathetic nerves
Sympathetic Nervous System - physiology
Thermogenesis
Thermogenesis - genetics
γ-Aminobutyric acid
γ-Aminobutyric acid A receptors
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-021-21107-5

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Abstract Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33 −/− mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33 f/f dopamine-β-hydroxylase ( DBH )-Cre mice indicates the importance of miR-33 in Dbh -positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA) A receptor subunit genes such as Gabrb2 and Gabra4 . Knock-down of these genes in Dbh -positive neurons rescues the impaired cold-induced thermogenesis in miR-33 f/f DBH -Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress. Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
AbstractList Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33 −/− mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33 f/f dopamine-β-hydroxylase ( DBH )-Cre mice indicates the importance of miR-33 in Dbh -positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA) A receptor subunit genes such as Gabrb2 and Gabra4 . Knock-down of these genes in Dbh -positive neurons rescues the impaired cold-induced thermogenesis in miR-33 f/f DBH -Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress.
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33 mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33 dopamine-β-hydroxylase (DBH)-Cre mice indicates the importance of miR-33 in Dbh-positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA) receptor subunit genes such as Gabrb2 and Gabra4. Knock-down of these genes in Dbh-positive neurons rescues the impaired cold-induced thermogenesis in miR-33 DBH-Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress.
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33 −/− mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33 f/f dopamine-β-hydroxylase ( DBH )-Cre mice indicates the importance of miR-33 in Dbh -positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA) A receptor subunit genes such as Gabrb2 and Gabra4 . Knock-down of these genes in Dbh -positive neurons rescues the impaired cold-induced thermogenesis in miR-33 f/f DBH -Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress. Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33−/− mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33f/f dopamine-β-hydroxylase (DBH)-Cre mice indicates the importance of miR-33 in Dbh-positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA)A receptor subunit genes such as Gabrb2 and Gabra4. Knock-down of these genes in Dbh-positive neurons rescues the impaired cold-induced thermogenesis in miR-33f/fDBH-Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress.Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33-/- mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33f/f dopamine-β-hydroxylase (DBH)-Cre mice indicates the importance of miR-33 in Dbh-positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA)A receptor subunit genes such as Gabrb2 and Gabra4. Knock-down of these genes in Dbh-positive neurons rescues the impaired cold-induced thermogenesis in miR-33f/f DBH-Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress.Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33-/- mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose tissue (BAT) thermogenesis. Analysis of miR-33f/f dopamine-β-hydroxylase (DBH)-Cre mice indicates the importance of miR-33 in Dbh-positive cells. Mechanistically, miR-33 deficiency upregulates gamma-aminobutyric acid (GABA)A receptor subunit genes such as Gabrb2 and Gabra4. Knock-down of these genes in Dbh-positive neurons rescues the impaired cold-induced thermogenesis in miR-33f/f DBH-Cre mice. Conversely, increased gene dosage of miR-33 in mice enhances thermogenesis. Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. This miR-33-mediated neural mechanism may serve as a physiological adaptive defense mechanism for several stresses including cold stress.
ArticleNumber 843
Author Nishiga, Masataka
Nakashima, Yasuhiro
Watanabe, Toshimitsu
Nishino, Tomohiro
Xu, Sijia
Picciotto, Marina R.
Nakao, Tetsushi
Tsuji, Shuhei
Yamasaki, Tomohiro
Sowa, Naoya
Ide, Yuya
Nakamura, Kazuhiro
Matsushita, Kazuki
Miyagawa, Sawa
Omori, Aoi
Matsumura, Shigenobu
Nishimura, Chika
Horie, Takahiro
Otani, Chiharu
Watanabe, Shin
Sasaki, Tsutomu
Miyasaka, Yui
Nishi, Hitoo
Ono, Koh
Kuwabara, Yasuhide
Kimura, Masahiro
Tanaka, Jin
Nakazeki, Fumiko
Rodriguez, Randolph Ruiz
Watanabe, Dai
Kimura, Takeshi
Inoue, Haruhisa
Baba, Osamu
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33594062$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/B978-0-12-411619-1.00011-2
10.1056/NEJMoa0808718
10.1128/MCB.00016-13
10.1038/nature10486
10.1002/cne.10643
10.1161/JAHA.112.003376
10.1194/jlr.M092379
10.1016/j.stem.2013.01.009
10.15252/emmm.201404046
10.1038/nm.3361
10.1016/S0092-8674(04)00045-5
10.1056/NEJMoa0808949
10.1016/j.ebiom.2015.04.004
10.1016/j.celrep.2018.01.074
10.1161/HYPERTENSIONAHA.111.00633
10.1016/j.cmet.2014.02.007
10.1007/s00424-017-2090-z
10.1038/nature13477
10.1161/CIRCRESAHA.116.309528
10.1042/BJ20091827
10.1161/JAHA.119.012609
10.1161/ATVBAHA.117.309768
10.1016/j.cmet.2012.11.006
10.1038/nn.4084
10.1146/annurev-physiol-020518-114546
10.1126/science.1189862
10.1038/nature11260
10.1016/j.cell.2007.11.019
10.1056/NEJMoa0810780
10.1161/ATVBAHA.118.311409
10.1253/circj.CJ-14-1252
10.1016/j.bbi.2015.02.008
10.1016/j.cmet.2014.05.018
10.1126/scitranslmed.3006840
10.1159/000492522
10.1152/ajpregu.00515.2003
10.1126/science.1189123
10.1042/CS20180980
10.1113/jphysiol.2011.210047
10.1523/JNEUROSCI.2053-15.2015
10.1038/ijo.2008.102
10.1172/JCI57275
10.1038/srep05312
10.1242/jeb.050989
10.1038/ncomms4224
10.1002/jnr.20229
10.1016/j.cmet.2016.12.002
10.1152/ajpendo.00097.2017
10.1038/nm.3589
10.1038/nbt.1515
10.1152/physrev.00007.2009
10.1016/j.bbalip.2018.05.003
10.1073/pnas.1008499107
10.1523/JNEUROSCI.1219-04.2004
10.1016/j.febslet.2015.04.025
10.1038/nrm3313
10.1074/jbc.271.43.26461
10.1016/j.biocel.2007.05.002
10.1038/ncomms3883
10.1038/s41467-018-07033-z
10.1111/ejn.13966
10.3791/51863
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References Horie (CR14) 2012; 1
Jovasevic (CR35) 2015; 18
CR38
Nakao (CR15) 2017; 37
Kondo (CR37) 2013; 12
Rzechorzek, Connick, Patani, Selvaraj, Chandran (CR30) 2015; 2
Bartel (CR8) 2004; 116
DiBona (CR53) 2013; 61
Nakamura, Morrison (CR44) 2011; 589
Goody, Pfeifer (CR9) 2019; 1864
Rayner (CR13) 2011; 121
Kelly, Yang, Chen, Reynolds, He (CR1) 2008; 32
Dutta (CR51) 2012; 487
Rayner (CR11) 2010; 328
Ramirez, Claret (CR33) 2015; 589
Horie (CR16) 2014; 4
Matsui (CR62) 2018; 9
CR40
Nishiga (CR58) 2017; 120
Heidt (CR52) 2014; 20
Hiraoka (CR59) 2014; 5
Rottiers, Naar (CR48) 2012; 13
Horie (CR12) 2010; 107
Morrison, Madden, Tupone (CR7) 2014; 19
Foust (CR39) 2009; 27
van Marken Lichtenbelt (CR3) 2009; 360
Kataoka, Hioki, Kaneko, Nakamura (CR43) 2014; 20
Rottiers (CR19) 2013; 5
von Essen, Lindsund, Cannon, Nedergaard (CR23) 2017; 313
Najafi-Shoushtari (CR10) 2010; 328
Nakamura, Nakamura (CR41) 2018; 470
Tsukita (CR25) 2012; 16
Sun (CR31) 2018; 48
Damiano, Alemanno, Gnoni, Siculella (CR56) 2010; 429
Goedeke (CR21) 2014; 6
Nakazeki (CR36) 2019; 133
Nakamura, Yanagawa, Morrison, Nakamura (CR57) 2017; 25
Koyama (CR55) 2019; 8
Harms, Seale (CR27) 2013; 19
Ono (CR49) 2015; 79
Vaughan, Zarebidaki, Ehlen, Bartness (CR28) 2014; 537
Colgan, Tang, Werstuck, Austin (CR46) 2007; 39
Rayner (CR18) 2011; 478
Nishino (CR17) 2018; 38
Nakamura (CR29) 2004; 24
Morrison, Nakamura (CR6) 2019; 81
Ramirez (CR50) 2013; 33
Horie (CR20) 2013; 4
Kim (CR26) 2015; 35
Madden, Morrison (CR45) 2004; 286
Kwong, Jamil, Rhodes, Taib, Chung (CR60) 2019; 60
Sato (CR47) 1996; 271
Cypess (CR4) 2009; 360
Feng, Lin, Wei (CR32) 2015; 46
Takahashi (CR61) 2007; 131
Virtanen (CR5) 2009; 360
Price (CR22) 2018; 22
Matsushita, Kobayashi, Miyazaki, Kobayashi (CR34) 2004; 78
Cano (CR42) 2003; 460
Peirce, Carobbio, Vidal-Puig (CR2) 2014; 510
Malpas (CR54) 2010; 90
Cannon, Nedergaard (CR24) 2011; 214
K Ono (21107_CR49) 2015; 79
Y Hiraoka (21107_CR59) 2014; 5
G Cano (21107_CR42) 2003; 460
S Koyama (21107_CR55) 2019; 8
V Rottiers (21107_CR48) 2012; 13
P Dutta (21107_CR51) 2012; 487
N Matsushita (21107_CR34) 2004; 78
D Goody (21107_CR9) 2019; 1864
G von Essen (21107_CR23) 2017; 313
SF Morrison (21107_CR7) 2014; 19
B Cannon (21107_CR24) 2011; 214
NM Rzechorzek (21107_CR30) 2015; 2
SC Malpas (21107_CR54) 2010; 90
Y Nakamura (21107_CR57) 2017; 25
SM Colgan (21107_CR46) 2007; 39
V Rottiers (21107_CR19) 2013; 5
T Kondo (21107_CR37) 2013; 12
K Nakamura (21107_CR44) 2011; 589
V Jovasevic (21107_CR35) 2015; 18
WD van Marken Lichtenbelt (21107_CR3) 2009; 360
N Kataoka (21107_CR43) 2014; 20
SF Morrison (21107_CR6) 2019; 81
F Damiano (21107_CR56) 2010; 429
AM Cypess (21107_CR4) 2009; 360
NL Price (21107_CR22) 2018; 22
J Kim (21107_CR26) 2015; 35
21107_CR40
KJ Rayner (21107_CR13) 2011; 121
CM Ramirez (21107_CR50) 2013; 33
T Horie (21107_CR20) 2013; 4
T Horie (21107_CR16) 2014; 4
S Tsukita (21107_CR25) 2012; 16
DP Bartel (21107_CR8) 2004; 116
F Nakazeki (21107_CR36) 2019; 133
T Kelly (21107_CR1) 2008; 32
T Heidt (21107_CR52) 2014; 20
21107_CR38
T Nishino (21107_CR17) 2018; 38
SH Najafi-Shoushtari (21107_CR10) 2010; 328
KJ Rayner (21107_CR11) 2010; 328
T Horie (21107_CR14) 2012; 1
Y Nakamura (21107_CR41) 2018; 470
KD Foust (21107_CR39) 2009; 27
K Nakamura (21107_CR29) 2004; 24
KA Virtanen (21107_CR5) 2009; 360
T Nakao (21107_CR15) 2017; 37
R Sato (21107_CR47) 1996; 271
M Harms (21107_CR27) 2013; 19
L Goedeke (21107_CR21) 2014; 6
GF DiBona (21107_CR53) 2013; 61
K Takahashi (21107_CR61) 2007; 131
SC Kwong (21107_CR60) 2019; 60
KJ Rayner (21107_CR18) 2011; 478
S Ramirez (21107_CR33) 2015; 589
M Nishiga (21107_CR58) 2017; 120
T Horie (21107_CR12) 2010; 107
X Feng (21107_CR32) 2015; 46
CH Vaughan (21107_CR28) 2014; 537
CJ Madden (21107_CR45) 2004; 286
S Matsui (21107_CR62) 2018; 9
V Peirce (21107_CR2) 2014; 510
Y Sun (21107_CR31) 2018; 48
References_xml – volume: 537
  start-page: 199
  year: 2014
  end-page: 225
  ident: CR28
  article-title: Analysis and measurement of the sympathetic and sensory innervation of white and brown adipose tissue
  publication-title: Methods Enzymol.
  doi: 10.1016/B978-0-12-411619-1.00011-2
– volume: 360
  start-page: 1500
  year: 2009
  end-page: 1508
  ident: CR3
  article-title: Cold-activated brown adipose tissue in healthy men
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0808718
– volume: 33
  start-page: 2891
  year: 2013
  end-page: 2902
  ident: CR50
  article-title: MicroRNA 33 regulates glucose metabolism
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00016-13
– volume: 478
  start-page: 404
  year: 2011
  end-page: 407
  ident: CR18
  article-title: Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
  publication-title: Nature
  doi: 10.1038/nature10486
– volume: 460
  start-page: 303
  year: 2003
  end-page: 326
  ident: CR42
  article-title: Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.10643
– volume: 1
  start-page: e003376
  year: 2012
  ident: CR14
  article-title: MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.112.003376
– volume: 60
  start-page: 1807
  year: 2019
  end-page: 1817
  ident: CR60
  article-title: Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-alpha signaling
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M092379
– volume: 12
  start-page: 487
  year: 2013
  end-page: 496
  ident: CR37
  article-title: Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.01.009
– volume: 6
  start-page: 1133
  year: 2014
  end-page: 1141
  ident: CR21
  article-title: Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201404046
– volume: 19
  start-page: 1252
  year: 2013
  end-page: 1263
  ident: CR27
  article-title: Brown and beige fat: development, function and therapeutic potential
  publication-title: Nat. Med.
  doi: 10.1038/nm.3361
– volume: 116
  start-page: 281
  year: 2004
  end-page: 297
  ident: CR8
  article-title: MicroRNAs: genomics, biogenesis, mechanism, and function
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00045-5
– volume: 360
  start-page: 1518
  year: 2009
  end-page: 1525
  ident: CR5
  article-title: Functional brown adipose tissue in healthy adults
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0808949
– volume: 2
  start-page: 528
  year: 2015
  end-page: 535
  ident: CR30
  article-title: Hypothermic preconditioning of human cortical neurons requires proteostatic priming
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2015.04.004
– volume: 22
  start-page: 2133
  year: 2018
  end-page: 2145
  ident: CR22
  article-title: Genetic ablation of miR-33 increases food intake, enhances adipose tissue expansion, and promotes obesity and insulin resistance
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.01.074
– volume: 61
  start-page: 556
  year: 2013
  end-page: 560
  ident: CR53
  article-title: Sympathetic nervous system and hypertension
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.00633
– volume: 19
  start-page: 741
  year: 2014
  end-page: 756
  ident: CR7
  article-title: Central neural regulation of brown adipose tissue thermogenesis and energy expenditure
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.02.007
– volume: 470
  start-page: 823
  year: 2018
  end-page: 837
  ident: CR41
  article-title: Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability
  publication-title: Pflug. Arch.
  doi: 10.1007/s00424-017-2090-z
– volume: 510
  start-page: 76
  year: 2014
  end-page: 83
  ident: CR2
  article-title: The different shades of fat
  publication-title: Nature
  doi: 10.1038/nature13477
– volume: 120
  start-page: 835
  year: 2017
  end-page: 847
  ident: CR58
  article-title: MicroRNA-33 controls adaptive fibrotic response in the remodeling heart by preserving lipid raft cholesterol
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.309528
– volume: 429
  start-page: 603
  year: 2010
  end-page: 612
  ident: CR56
  article-title: Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site
  publication-title: Biochem. J.
  doi: 10.1042/BJ20091827
– volume: 8
  start-page: e012609
  year: 2019
  ident: CR55
  article-title: Identification of differential roles of microRNA-33a and -33b during atherosclerosis progression with genetically modified mice
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.012609
– volume: 37
  start-page: 2161
  year: 2017
  end-page: 2170
  ident: CR15
  article-title: Genetic ablation of microRNA-33 attenuates inflammation and abdominal aortic aneurysm formation via several anti-inflammatory pathways
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.117.309768
– volume: 16
  start-page: 825
  year: 2012
  end-page: 832
  ident: CR25
  article-title: Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.11.006
– volume: 18
  start-page: 1265
  year: 2015
  end-page: 1271
  ident: CR35
  article-title: GABAergic mechanisms regulated by miR-33 encode state-dependent fear
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4084
– volume: 81
  start-page: 285
  year: 2019
  end-page: 308
  ident: CR6
  article-title: Central mechanisms for thermoregulation
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114546
– volume: 328
  start-page: 1570
  year: 2010
  end-page: 1573
  ident: CR11
  article-title: MiR-33 contributes to the regulation of cholesterol homeostasis
  publication-title: Science
  doi: 10.1126/science.1189862
– volume: 487
  start-page: 325
  year: 2012
  end-page: 329
  ident: CR51
  article-title: Myocardial infarction accelerates atherosclerosis
  publication-title: Nature
  doi: 10.1038/nature11260
– volume: 131
  start-page: 861
  year: 2007
  end-page: 872
  ident: CR61
  article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors
  publication-title: Cell
  doi: 10.1016/j.cell.2007.11.019
– volume: 360
  start-page: 1509
  year: 2009
  end-page: 1517
  ident: CR4
  article-title: Identification and importance of brown adipose tissue in adult humans
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0810780
– volume: 38
  start-page: 2460
  year: 2018
  end-page: 2473
  ident: CR17
  article-title: SREBF1/microRNA-33b axis exhibits potent effect on unstable atherosclerotic plaque formation in vivo
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.311409
– volume: 79
  start-page: 278
  year: 2015
  end-page: 284
  ident: CR49
  article-title: MicroRNA-33a/b in lipid metabolism—novel “thrifty” models
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-14-1252
– volume: 46
  start-page: 270
  year: 2015
  end-page: 279
  ident: CR32
  article-title: Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2015.02.008
– volume: 20
  start-page: 346
  year: 2014
  end-page: 358
  ident: CR43
  article-title: Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.05.018
– volume: 5
  start-page: 212ra162
  year: 2013
  ident: CR19
  article-title: Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006840
– volume: 48
  start-page: 1995
  year: 2018
  end-page: 2010
  ident: CR31
  article-title: Endoplasmic reticulum stress affects lipid metabolism in atherosclerosis via CHOP activation and over-expression of miR-33
  publication-title: Cell Physiol. Biochem.
  doi: 10.1159/000492522
– volume: 286
  start-page: R320
  year: 2004
  end-page: R325
  ident: CR45
  article-title: Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00515.2003
– volume: 328
  start-page: 1566
  year: 2010
  end-page: 1569
  ident: CR10
  article-title: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
  publication-title: Science
  doi: 10.1126/science.1189123
– volume: 133
  start-page: 583
  year: 2019
  end-page: 595
  ident: CR36
  article-title: MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons
  publication-title: Clin. Sci.
  doi: 10.1042/CS20180980
– volume: 589
  start-page: 3641
  year: 2011
  end-page: 3658
  ident: CR44
  article-title: Central efferent pathways for cold-defensive and febrile shivering
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2011.210047
– volume: 35
  start-page: 14717
  year: 2015
  end-page: 14726
  ident: CR26
  article-title: microRNA-33 regulates ApoE lipidation and amyloid-beta metabolism in the brain
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2053-15.2015
– volume: 32
  start-page: 1431
  year: 2008
  end-page: 1437
  ident: CR1
  article-title: Global burden of obesity in 2005 and projections to 2030
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2008.102
– volume: 121
  start-page: 2921
  year: 2011
  end-page: 2931
  ident: CR13
  article-title: Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI57275
– volume: 4
  year: 2014
  ident: CR16
  article-title: MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo
  publication-title: Sci. Rep.
  doi: 10.1038/srep05312
– ident: CR40
– volume: 214
  start-page: 242
  year: 2011
  end-page: 253
  ident: CR24
  article-title: Nonshivering thermogenesis and its adequate measurement in metabolic studies
  publication-title: J. Exp. Biol.
  doi: 10.1242/jeb.050989
– volume: 5
  year: 2014
  ident: CR59
  article-title: Critical roles of nardilysin in the maintenance of body temperature homoeostasis
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4224
– volume: 78
  start-page: 7
  year: 2004
  end-page: 15
  ident: CR34
  article-title: Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.20229
– volume: 25
  start-page: 322
  year: 2017
  end-page: 334
  ident: CR57
  article-title: Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.12.002
– volume: 313
  start-page: E515
  year: 2017
  end-page: E527
  ident: CR23
  article-title: Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00097.2017
– ident: CR38
– volume: 20
  start-page: 754
  year: 2014
  end-page: 758
  ident: CR52
  article-title: Chronic variable stress activates hematopoietic stem cells
  publication-title: Nat. Med.
  doi: 10.1038/nm.3589
– volume: 27
  start-page: 59
  year: 2009
  end-page: 65
  ident: CR39
  article-title: Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1515
– volume: 90
  start-page: 513
  year: 2010
  end-page: 557
  ident: CR54
  article-title: Sympathetic nervous system overactivity and its role in the development of cardiovascular disease
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00007.2009
– volume: 1864
  start-page: 29
  year: 2019
  end-page: 36
  ident: CR9
  article-title: MicroRNAs in brown and beige fat
  publication-title: Biochim. Biophys. Acta Mol. Cell Biol. Lipids
  doi: 10.1016/j.bbalip.2018.05.003
– volume: 107
  start-page: 17321
  year: 2010
  end-page: 17326
  ident: CR12
  article-title: MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008499107
– volume: 24
  start-page: 5370
  year: 2004
  end-page: 5380
  ident: CR29
  article-title: Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1219-04.2004
– volume: 589
  start-page: 1678
  year: 2015
  end-page: 1687
  ident: CR33
  article-title: Hypothalamic ER stress: a bridge between leptin resistance and obesity
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2015.04.025
– volume: 13
  start-page: 239
  year: 2012
  end-page: 250
  ident: CR48
  article-title: MicroRNAs in metabolism and metabolic disorders
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3313
– volume: 271
  start-page: 26461
  year: 1996
  end-page: 26464
  ident: CR47
  article-title: Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.43.26461
– volume: 39
  start-page: 1843
  year: 2007
  end-page: 1851
  ident: CR46
  article-title: Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2007.05.002
– volume: 4
  year: 2013
  ident: CR20
  article-title: MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3883
– volume: 9
  year: 2018
  ident: CR62
  article-title: Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07033-z
– volume: 328
  start-page: 1566
  year: 2010
  ident: 21107_CR10
  publication-title: Science
  doi: 10.1126/science.1189123
– volume: 4
  year: 2014
  ident: 21107_CR16
  publication-title: Sci. Rep.
  doi: 10.1038/srep05312
– ident: 21107_CR40
  doi: 10.1111/ejn.13966
– volume: 470
  start-page: 823
  year: 2018
  ident: 21107_CR41
  publication-title: Pflug. Arch.
  doi: 10.1007/s00424-017-2090-z
– volume: 33
  start-page: 2891
  year: 2013
  ident: 21107_CR50
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00016-13
– volume: 313
  start-page: E515
  year: 2017
  ident: 21107_CR23
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00097.2017
– volume: 20
  start-page: 754
  year: 2014
  ident: 21107_CR52
  publication-title: Nat. Med.
  doi: 10.1038/nm.3589
– volume: 360
  start-page: 1509
  year: 2009
  ident: 21107_CR4
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0810780
– volume: 271
  start-page: 26461
  year: 1996
  ident: 21107_CR47
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.43.26461
– volume: 8
  start-page: e012609
  year: 2019
  ident: 21107_CR55
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.012609
– volume: 25
  start-page: 322
  year: 2017
  ident: 21107_CR57
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.12.002
– volume: 12
  start-page: 487
  year: 2013
  ident: 21107_CR37
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.01.009
– volume: 81
  start-page: 285
  year: 2019
  ident: 21107_CR6
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114546
– volume: 1
  start-page: e003376
  year: 2012
  ident: 21107_CR14
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.112.003376
– volume: 214
  start-page: 242
  year: 2011
  ident: 21107_CR24
  publication-title: J. Exp. Biol.
  doi: 10.1242/jeb.050989
– volume: 38
  start-page: 2460
  year: 2018
  ident: 21107_CR17
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.311409
– volume: 460
  start-page: 303
  year: 2003
  ident: 21107_CR42
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.10643
– volume: 48
  start-page: 1995
  year: 2018
  ident: 21107_CR31
  publication-title: Cell Physiol. Biochem.
  doi: 10.1159/000492522
– volume: 589
  start-page: 1678
  year: 2015
  ident: 21107_CR33
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2015.04.025
– volume: 510
  start-page: 76
  year: 2014
  ident: 21107_CR2
  publication-title: Nature
  doi: 10.1038/nature13477
– volume: 37
  start-page: 2161
  year: 2017
  ident: 21107_CR15
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.117.309768
– volume: 18
  start-page: 1265
  year: 2015
  ident: 21107_CR35
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4084
– volume: 286
  start-page: R320
  year: 2004
  ident: 21107_CR45
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00515.2003
– ident: 21107_CR38
  doi: 10.3791/51863
– volume: 589
  start-page: 3641
  year: 2011
  ident: 21107_CR44
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2011.210047
– volume: 116
  start-page: 281
  year: 2004
  ident: 21107_CR8
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00045-5
– volume: 9
  year: 2018
  ident: 21107_CR62
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07033-z
– volume: 6
  start-page: 1133
  year: 2014
  ident: 21107_CR21
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201404046
– volume: 328
  start-page: 1570
  year: 2010
  ident: 21107_CR11
  publication-title: Science
  doi: 10.1126/science.1189862
– volume: 24
  start-page: 5370
  year: 2004
  ident: 21107_CR29
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1219-04.2004
– volume: 20
  start-page: 346
  year: 2014
  ident: 21107_CR43
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.05.018
– volume: 537
  start-page: 199
  year: 2014
  ident: 21107_CR28
  publication-title: Methods Enzymol.
  doi: 10.1016/B978-0-12-411619-1.00011-2
– volume: 19
  start-page: 1252
  year: 2013
  ident: 21107_CR27
  publication-title: Nat. Med.
  doi: 10.1038/nm.3361
– volume: 1864
  start-page: 29
  year: 2019
  ident: 21107_CR9
  publication-title: Biochim. Biophys. Acta Mol. Cell Biol. Lipids
  doi: 10.1016/j.bbalip.2018.05.003
– volume: 46
  start-page: 270
  year: 2015
  ident: 21107_CR32
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2015.02.008
– volume: 60
  start-page: 1807
  year: 2019
  ident: 21107_CR60
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M092379
– volume: 22
  start-page: 2133
  year: 2018
  ident: 21107_CR22
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.01.074
– volume: 27
  start-page: 59
  year: 2009
  ident: 21107_CR39
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1515
– volume: 429
  start-page: 603
  year: 2010
  ident: 21107_CR56
  publication-title: Biochem. J.
  doi: 10.1042/BJ20091827
– volume: 107
  start-page: 17321
  year: 2010
  ident: 21107_CR12
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008499107
– volume: 61
  start-page: 556
  year: 2013
  ident: 21107_CR53
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.00633
– volume: 39
  start-page: 1843
  year: 2007
  ident: 21107_CR46
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2007.05.002
– volume: 2
  start-page: 528
  year: 2015
  ident: 21107_CR30
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2015.04.004
– volume: 19
  start-page: 741
  year: 2014
  ident: 21107_CR7
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.02.007
– volume: 5
  start-page: 212ra162
  year: 2013
  ident: 21107_CR19
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006840
– volume: 120
  start-page: 835
  year: 2017
  ident: 21107_CR58
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.309528
– volume: 121
  start-page: 2921
  year: 2011
  ident: 21107_CR13
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI57275
– volume: 5
  year: 2014
  ident: 21107_CR59
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4224
– volume: 90
  start-page: 513
  year: 2010
  ident: 21107_CR54
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00007.2009
– volume: 35
  start-page: 14717
  year: 2015
  ident: 21107_CR26
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2053-15.2015
– volume: 133
  start-page: 583
  year: 2019
  ident: 21107_CR36
  publication-title: Clin. Sci.
  doi: 10.1042/CS20180980
– volume: 79
  start-page: 278
  year: 2015
  ident: 21107_CR49
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-14-1252
– volume: 78
  start-page: 7
  year: 2004
  ident: 21107_CR34
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.20229
– volume: 32
  start-page: 1431
  year: 2008
  ident: 21107_CR1
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2008.102
– volume: 478
  start-page: 404
  year: 2011
  ident: 21107_CR18
  publication-title: Nature
  doi: 10.1038/nature10486
– volume: 16
  start-page: 825
  year: 2012
  ident: 21107_CR25
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.11.006
– volume: 131
  start-page: 861
  year: 2007
  ident: 21107_CR61
  publication-title: Cell
  doi: 10.1016/j.cell.2007.11.019
– volume: 13
  start-page: 239
  year: 2012
  ident: 21107_CR48
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3313
– volume: 360
  start-page: 1500
  year: 2009
  ident: 21107_CR3
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0808718
– volume: 4
  year: 2013
  ident: 21107_CR20
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3883
– volume: 487
  start-page: 325
  year: 2012
  ident: 21107_CR51
  publication-title: Nature
  doi: 10.1038/nature11260
– volume: 360
  start-page: 1518
  year: 2009
  ident: 21107_CR5
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0808949
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Snippet Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the...
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown...
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proquest
pubmed
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springer
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Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 843
SubjectTerms 45/41
64/60
692/308/1426
692/699/317
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - physiology
Animals
Body temperature
Body Temperature - physiology
Body Weight
Brain
Brain - metabolism
Cell Line
Circuits
Cold
Cold Temperature
Diet, High-Fat
Dopamine
Dopamine β-monooxygenase
Endoplasmic Reticulum Stress
Energy balance
Gene dosage
Genes
Humanities and Social Sciences
Humans
Hydroxylase
Hypothalamus
Integrases - metabolism
Maintenance
Male
Mice
Mice, Obese
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
multidisciplinary
Neurotransmission
Oxygen Consumption - physiology
Phenotype
Protein Subunits - genetics
Protein Subunits - metabolism
Receptors
Receptors, GABA-A - genetics
Receptors, GABA-A - metabolism
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Sympathetic nerves
Sympathetic Nervous System - physiology
Thermogenesis
Thermogenesis - genetics
γ-Aminobutyric acid
γ-Aminobutyric acid A receptors
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Title microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
URI https://link.springer.com/article/10.1038/s41467-021-21107-5
https://www.ncbi.nlm.nih.gov/pubmed/33594062
https://www.proquest.com/docview/2489905889
https://www.proquest.com/docview/2492999739
https://pubmed.ncbi.nlm.nih.gov/PMC7886914
https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f
Volume 12
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