Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility

• Published in: Journal of allergy and clinical immunology Vol. 124; no. 6; pp. 1204 - 1209.e9
• Main Authors: Haller, Gabe, Torgerson, Dara G., Ober, Carole, Thompson, Emma E.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2009; Elsevier; Elsevier Limited
• Subjects: Accuracy; African Americans; Allergy and Immunology; Asthma; Asthma - genetics; Asthma - immunology; Biological and medical sciences; Black or African American - genetics; Chromosomes; Chronic obstructive pulmonary disease, asthma; Deoxyribonucleic acid; Disease; DNA; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Frequency - genetics; Gene Frequency - immunology; Gene polymorphism; Genes; Genetic diversity; Genetic Predisposition to Disease; Genotype; Genotyping; Humans; Hypotheses; IgE; IL4; Immunopathology; Interleukin 4; Interleukin-4 - genetics; Interleukin-4 - immunology; Introns - genetics; Linkage Disequilibrium - genetics; Medical sciences; Pneumology; Polymorphism, Single Nucleotide - genetics; Polymorphism, Single Nucleotide - immunology; Population; private alleles; Rare variants; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Single-nucleotide polymorphism; Studies; IL4; MAF; SNP; private alleles; IgE; Rare variants; African Americans; asthma; Single nucleotide polymorphism; Minor allele frequency; Genetic variability; Non coding sequence; Interleukin 4; Immunology; Bronchus disease; Genetics; Obstructive pulmonary disease; Locus; Sequencing; Human; Lung disease; Immunopathology; Nucleotide sequence; Respiratory disease; Cytokine; Genotype; Asthma; Variant; Allele; Sensitivity; African American

Common genetic variations in the IL4 gene have been associated with asthma and atopy in European and Asian populations, but not in African Americans. Because populations of African descent have increased levels of genetic variation compared with other populations, particularly with respect to low fr...