Pneumococcal meningitis in adults in 2014–2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan

We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual i...

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Published inScientific reports Vol. 12; no. 1; p. 3066
Main Authors Chang, Bin, Tamura, Kosuke, Fujikura, Hiroyuki, Watanabe, Hiroshi, Tanabe, Yoshinari, Kuronuma, Koji, Fujita, Jiro, Oshima, Kengo, Maruyama, Takaya, Abe, Shuichi, Kasahara, Kei, Nishi, Junichiro, Kubota, Tetsuya, Kinjo, Yuki, Serizawa, Yusuke, Shimbashi, Reiko, Fukusumi, Munehisa, Shimada, Tomoe, Sunagawa, Tomimasa, Suzuki, Motoi, Oishi, Kazunori
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.02.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/326
692/308
692/699
Adolescent
Adult
Age Factors
Aged
Ceftriaxone
Epidemiology
Female
Humanities and Social Sciences
Humans
Incidence
Japan - epidemiology
Male
Meningitis
Meningitis, Pneumococcal - epidemiology
Meningitis, Pneumococcal - microbiology
Meningitis, Pneumococcal - mortality
Middle Aged
multidisciplinary
Mutation
Patients
Pediatrics
Penicillin
Pneumococcal Infections - epidemiology
Pneumococcal Infections - mortality
Pneumococcal Vaccines
Science
Science (multidisciplinary)
Serogroup
Serotypes
Splenectomy - adverse effects
Splenectomy - statistics & numerical data
Streptococcus infections
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - isolation & purification
Time Factors
Vaccines
Young Adult
Japan
Online AccessGet full text

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Abstract We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population . Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1b A641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
AbstractList We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population . Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1b A641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
Abstract We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population . Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1b A641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014-2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016-2018 was 0.20-0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27-4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10-5.06) or 23A (aOR 3.91, 95% CI 2.47-6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44-0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51-5.65).
Abstract We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
ArticleNumber 3066
Author Oishi, Kazunori
Fujikura, Hiroyuki
Maruyama, Takaya
Kasahara, Kei
Serizawa, Yusuke
Tamura, Kosuke
Tanabe, Yoshinari
Abe, Shuichi
Shimada, Tomoe
Suzuki, Motoi
Shimbashi, Reiko
Kuronuma, Koji
Fukusumi, Munehisa
Fujita, Jiro
Oshima, Kengo
Kinjo, Yuki
Kubota, Tetsuya
Nishi, Junichiro
Chang, Bin
Watanabe, Hiroshi
Sunagawa, Tomimasa
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ContentType Journal Article
Contributor Fujikura, Hiroyuki
Gotoh, Kenji
Serizawa, Yusuke
Ishida, Masayuki
Tanabe, Yoshinari
Abe, Shuichi
Takahashi, Hiroki
Shimada, Tomoe
Suzuki, Motoi
Shimbashi, Reiko
Takeda, Hiroaki
Kuronuma, Koji
Fukusumi, Munehisa
Oshima, Kengo
Kinjo, Yuki
Nakamatsu, Masashi
Kubota, Tetsuya
Chang, Bin
Watanabe, Hiroshi
Sunagawa, Tomimasa
Imuta, Naoko
Aoyagi, Tetsuji
Oishi, Kazunori
Maruyama, Takaya
Kasahara, Kei
Tamura, Kosuke
Fujita, Jiro
Yokoyama, Akihito
Nishi, Junichiro
Tsubata, Chikako
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Snippet We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by...
We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014-2018 by...
Abstract We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by...
Abstract We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by...
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692/699
Adolescent
Adult
Age Factors
Aged
Ceftriaxone
Epidemiology
Female
Humanities and Social Sciences
Humans
Incidence
Japan - epidemiology
Male
Meningitis
Meningitis, Pneumococcal - epidemiology
Meningitis, Pneumococcal - microbiology
Meningitis, Pneumococcal - mortality
Middle Aged
multidisciplinary
Mutation
Patients
Pediatrics
Penicillin
Pneumococcal Infections - epidemiology
Pneumococcal Infections - mortality
Pneumococcal Vaccines
Science
Science (multidisciplinary)
Serogroup
Serotypes
Splenectomy - adverse effects
Splenectomy - statistics & numerical data
Streptococcus infections
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - isolation & purification
Time Factors
Vaccines
Young Adult
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Title Pneumococcal meningitis in adults in 2014–2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan
URI https://link.springer.com/article/10.1038/s41598-022-06950-w
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Volume 12
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