Reduced gonadotroph stimulation by ethanolamine plasmalogens in old bovine brains

• Published in: Scientific reports Vol. 11; no. 1; pp. 4757 - 12
• Main Authors: Kadokawa, Hiroya, Kotaniguchi, Miyako, Kereilwe, Onalenna, Kitamura, Shinichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/494/2732; 631/601/1737; Acyltransferase; Age; Biosynthesis; Brain; Cattle; Ethanolamine; Follicle-stimulating hormone; G protein-coupled receptors; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone receptors; Gonadotropins; Humanities and Social Sciences; Hypothalamus; Infertility; Liquid chromatography; Mass spectrometry; Mass spectroscopy; multidisciplinary; Pituitary (anterior); Polymerase chain reaction; Reverse transcription; Science; Science (multidisciplinary); Secretion

Ethanolamine plasmalogens (EPls), unique alkenylacyl-glycerophospholipids, are the only known ligands of G-protein-coupled receptor 61—a novel receptor co-localised with gonadotropin-releasing hormone receptors on anterior pituitary gonadotrophs. Brain EPl decreases with age. Commercial EPl—extracte...