Mechanical Downsizing of a Gadolinium(III)-based Metal-Organic Framework for Anticancer Drug Delivery

• Published in: Chemistry : a European journal Vol. 20; no. 33; pp. 10514 - 10518
• Main Authors: Kundu, Tanay, Mitra, Shouvik, Patra, Prasun, Goswami, Arunava, Díaz Díaz, David, Banerjee, Rahul
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 11.08.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Animals; Antineoplastic Agents - administration & dosage; ball-milling; Benzene; Benzene Derivatives - chemistry; Benzene Derivatives - pharmacokinetics; Biocompatibility; Chemistry; Crystallinity; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Doxorubicin; Doxorubicin - administration & dosage; drug delivery; Drug Delivery Systems; Drugs; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacokinetics; Gadolinium; Gadolinium - chemistry; Gadolinium - pharmacokinetics; Humans; Magnesium; Metal-organic frameworks; Metalorganic compounds; Mice; Models, Molecular; nanocarriers; Nanostructure; Neoplasms - drug therapy; Open channels; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacokinetics; Porosity; ball-milling; doxorubicin; drug delivery; nanocarriers; metal-organic frameworks

A GdIII‐based porous metal–organic framework (MOF), Gd‐pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4‐bis(5‐carboxy‐1H‐benzimidazole‐2‐yl)benzene)), resulting in a three‐dimensional interpenetrated structure with a one‐dimensional open channel (1.9×1.2 nm) filled with hydrogen‐b...