Conformational IgE epitopes of peanut allergens Ara h 2 and Ara h 6

• Published in: Clinical and experimental allergy Vol. 46; no. 8; pp. 1120 - 1128
• Main Authors: Chen, X., Negi, S. S., Liao, S., Gao, V., Braun, W., Dreskin, S. C.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2016; Wiley Subscription Services, Inc
• Subjects: 2S Albumins, Plant - chemistry; 2S Albumins, Plant - immunology; 2S Albumins, Plant - metabolism; allergens; Allergens - chemistry; Allergens - immunology; Allergens - metabolism; Allergies; Amino Acid Sequence; Antigens, Plant - chemistry; Antigens, Plant - immunology; Antigens, Plant - metabolism; Ara h 2; Ara h 6; Arachis - immunology; Arachis hypogaea; Binding Sites; Cell Surface Display Techniques; Consensus Sequence; EpiSearch; Epitope Mapping - methods; epitopes; Epitopes - chemistry; Epitopes - immunology; Epitopes - metabolism; Glycoproteins - chemistry; Glycoproteins - immunology; Glycoproteins - metabolism; Humans; IgE; Immunoglobulin E - chemistry; Immunoglobulin E - immunology; Immunoglobulin E - metabolism; mimotopes; Models, Molecular; peanut; Peanut Hypersensitivity - immunology; Peanuts; Peptide Library; phage display; Protein Binding; Protein Conformation; epitopes; mimotopes; EpiSearch; phage display; IgE; Ara h 6; peanut; Ara h 2; allergens

Summary Background Cross‐linking of IgE antibody by specific epitopes on the surface of mast cells is a prerequisite for triggering symptoms of peanut allergy. IgE epitopes are frequently categorized as linear or conformational epitopes. Although linear IgE‐binding epitopes of peanut allergens have...