Disruption of cortical integration during midazolam-induced light sedation

• Published in: Human brain mapping Vol. 36; no. 11; pp. 4247 - 4261
• Main Authors: Liang, Peipeng, Zhang, Han, Xu, Yachao, Jia, Wenbin, Zang, Yufeng, Li, Kuncheng
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2015; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adult; Cerebral Cortex - drug effects; Connectome - methods; Conscious Sedation; Double-Blind Method; Female; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacology; independent component analysis (ICA); Male; Mental Processes - drug effects; midazolam; Midazolam - administration & dosage; Midazolam - pharmacology; Nerve Net - drug effects; resting-state functional MRI (rs-fMRI); sedation; Young Adult; resting-state functional MRI (rs-fMRI); independent component analysis (ICA); midazolam; sedation

This work examines the effect of midazolam‐induced light sedation on intrinsic functional connectivity of human brain, using a randomized, double‐blind, placebo‐controlled, cross‐over, within‐subject design. Fourteen healthy young subjects were enrolled and midazolam (0.03 mg/kg of the participant&#...