Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 31; no. 9; pp. 2144 - 2150
• Main Authors: Taskinen, Marja-Riitta, Adiels, Martin, Westerbacka, Jukka, Söderlund, Sanni, Kahri, Juhani, Lundbom, Nina, Lundbom, Jesper, Hakkarainen, Antti, Olofsson, Sven-Olof, Orho-Melander, Marju, Borén, Jan
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.09.2011; Lippincott Williams & Wilkins
• Subjects: Abdominal Fat - metabolism; Adult; apoB-100; Apolipoprotein C-III - physiology; apolipoproteins; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiac and Cardiovascular Systems; Cardiology and Cardiovascular Disease; Cardiology. Vascular system; Cardiovascular system; Clinical Medicine; diabetes; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fatty Acids, Nonesterified - blood; Humans; Hypertriglyceridemia - etiology; Intra-Abdominal Fat - metabolism; Investigative techniques, diagnostic techniques (general aspects); Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; lipoproteins; Lipoproteins, VLDL - metabolism; Liver - metabolism; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; metabolic syndrome; metabolism; Middle Aged; obesity; Obesity - metabolism; triglycerides; Triglycerides - metabolism; Ultrasonic investigative techniques; Human; Obesity; apolipoproteins; Nutrition disorder; Metabolic diseases; Lipids; Cardiovascular disease; Hyperlipoproteinemia; Apolipoprotein; Lipoprotein; Metabolism; Triglyceride; Enzymopathy; Vascular disease; Hypertriglyceridemia; Atherosclerosis; Dyslipemia; Nutritional status; lipoproteins

OBJECTIVE—Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects. METHODS AND RESULTS—Stable...