Spatial navigation deficit in amnestic mild cognitive impairment

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 10; pp. 4042 - 4047
• Main Authors: Hort, Jakub, Laczó, Jan, Vyhnálek, Martin, Bojar, Martin, Bureš, Jan, Vlček, Kamil
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.03.2007; National Acad Sciences
• Subjects: Aged; Alzheimer disease; Alzheimer Disease - diagnosis; Alzheimer Disease - pathology; Alzheimer's disease; Alzheimers disease; Amnesia; Amnesia - diagnosis; Biological Sciences; Biomarkers; Cognition; Cognition Disorders - diagnosis; Cognitive ability; computer hardware; Control groups; Dementia; disease course; disease surveillance; early development; Female; Human subjects; Humans; Landmarks; Male; Memory; Memory Disorders; Memory, Short-Term; Middle Aged; Navigation; Neurology; Neuropsychological Tests; Neuropsychology; patients; Space Perception; Temporal lobe
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.0611314104

Patients with Alzheimer's disease (AD) frequently have difficulties with spatial orientation in their day-to-day life. Although AD is typically preceded by amnestic mild cognitive impairment (MCI), spatial navigation has not yet been studied in MCI. Sixty-five patients were divided into five gr...