Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease

• Published in: Thrombosis and haemostasis Vol. 101; no. 1; p. 123
• Main Authors: Kunicki, Thomas J, Williams, Shirley A, Nugent, Diane J, Harrison, Paul, Segal, Helen C, Syed, Anila, Rothwell, Peter M
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2009
• Subjects: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin - therapeutic use; Cohort Studies; Cyclooxygenase 1 - genetics; Drug Resistance - genetics; England; Epinephrine; Female; Gene Frequency; Haplotypes; Humans; Integrin alpha2 - genetics; Integrin beta3 - genetics; Male; Membrane Glycoproteins; Membrane Proteins - genetics; Middle Aged; Platelet Aggregation - drug effects; Platelet Aggregation - genetics; Platelet Aggregation Inhibitors - therapeutic use; Platelet Count; Platelet Function Tests - instrumentation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins - genetics; Polymorphism, Single Nucleotide; Receptors, Purinergic P2 - genetics; Treatment Failure; Up-Regulation; Vascular Diseases - blood; Vascular Diseases - drug therapy; Vascular Diseases - genetics; von Willebrand Factor - analysis; England

We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function Analyzer-100 (PFA-100). We correlated ASA responsiveness with haplotypes of seven candidate gen...