Immunologic heterogeneity of tumor infiltrating lymphocyte composition in primary melanoma

• Published in: Human pathology Vol. 57; pp. 116 - 125
• Main Authors: Weiss, Sarah A., MD, Han, Sung Won, PhD, Lui, Kevin, MS, Tchack, Jeremy, BA, Shapiro, Richard, MD, Berman, Russell, MD, Zhong, Judy, PhD, Krogsgaard, Michelle, PhD, Osman, Iman, MD, Darvishian, Farbod, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: Aged; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Brisk; Cancer; CD3 Complex - analysis; Disease-Free Survival; Female; Forkhead Transcription Factors - analysis; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Host immune response; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Laboratories; Leukocyte Common Antigens - analysis; Lymphocytes, Tumor-Infiltrating - immunology; Male; Medical prognosis; Melanoma; Melanoma - genetics; Melanoma - immunology; Melanoma - pathology; Melanoma - therapy; Neoplasm Grading; Pathology; Patients; Phenotype; Prognosis; Proportional Hazards Models; Skin Neoplasms - genetics; Skin Neoplasms - immunology; Skin Neoplasms - pathology; Skin Neoplasms - therapy; Studies; Time Factors; Treatment Outcome; Tumor-infiltrating lymphocytes; host immune response; IHC; tumor infiltrating lymphocyte; formalin-fixed paraffin embedded; high power field; Institutional Review Board; American Joint Committee on Cancer; SLN; FFPE; recurrence-free survival; tumor infiltrating lymphocytes; AJCC; overall survival; immunohistochemistry; RFS; hematoxylin and eosin; T regulatory cell; OS; CI; H&E; Treg; Interdisciplinary Melanoma Cooperative Group; sentinel lymph node; melanoma; IMCG; NYU; prognosis; vertical growth phase; Integrative Pathway Analysis; TIL; IRB; New York University; confidence interval; IPA; VGP; HPF; Prognosis; Tumor-infiltrating lymphocytes; Brisk; Melanoma; Host immune response

Tumor infiltrating lymphocytes (TILs) in primary melanomas are thought to represent the host anti-tumor immune response, but controversy exists over whether TILs offer independent prognostication of survival. We studied a cohort of 1241 primary melanoma patients to assess the association of absent,...