FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats[S]
The farnesoid X receptor (FXR) is a bile acid activated nuclear receptor. Zucker (fa/fa) rats, harboring a loss of function mutation of the leptin receptor, develop diabetes, insulin resistance, obesity, and liver steatosis. In this study, we investigated the effect of FXR activation by 6-ethyl-chen...
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Published in | Journal of lipid research Vol. 51; no. 4; pp. 771 - 784 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.04.2010
American Society for Biochemistry and Molecular Biology The American Society for Biochemistry and Molecular Biology Elsevier |
Subjects | |
Online Access | Get full text |
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