Novel approaches to whole sporozoite vaccination against malaria

• Published in: Vaccine Vol. 33; no. 52; pp. 7462 - 7468
• Main Authors: Bijker, Else M, Borrmann, Steffen, Kappe, Stefan H, Mordmüller, Benjamin, Sack, Brandon K, Khan, Shahid M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 22.12.2015; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antimalarials - therapeutic use; Chemoprophylaxis; Chloroquine; Chloroquine - therapeutic use; Drug Evaluation, Preclinical; Genetic attenuation; Humans; Immunization; Liver stage; Malaria; Malaria - immunology; Malaria - prevention & control; Malaria Vaccines - genetics; Malaria Vaccines - immunology; Mice; Mosquitoes; Parasites; Plasmodium; Plasmodium - immunology; Plasmodium falciparum - genetics; Plasmodium falciparum - immunology; Pre-erythrocytic stages; Pre-Exposure Prophylaxis; Sporozoite; Sporozoites - immunology; Sporozoites - radiation effects; Vaccination - methods; Vaccine; Vaccines; Vaccines, Attenuated - immunology; Plasmodium; Immunization; Chemoprophylaxis; Malaria; Genetic attenuation; Chloroquine; Liver stage; Sporozoite; Vaccine; Pre-erythrocytic stages

Abstract The parasitic disease malaria threatens more than 3 billion people worldwide, resulting in more than 200 million clinical cases and almost 600,000 deaths annually. Vaccines remain crucial for prevention and ultimately eradication of infectious diseases and, for malaria, whole sporozoite bas...