Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion

• Published in: Journal of applied physiology (1985) Vol. 104; no. 5; pp. 1485 - 1494
• Main Authors: Otto, Cynthia M, Markstaller, Klaus, Kajikawa, Osamu, Karmrodt, Jens, Syring, Rebecca S, Pfeiffer, Birgit, Good, Virginia P, Frevert, Charles W, Baumgardner, James E
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.05.2008; American Physiological Society
• Subjects: Animals; Biological and medical sciences; Blood Gas Analysis; Calibration; Chemokine CCL2 - metabolism; Chemokines - metabolism; Comparative analysis; Cytokines; Cytokines - metabolism; Edema; Enzymatic activity; Enzyme-Linked Immunosorbent Assay; Female; Fluid Therapy; Fundamental and applied biological sciences. Psychology; Heterogeneity; Injuries; Interleukin-8 - biosynthesis; Lung - pathology; Lung Injury; Lungs; Neutrophil Infiltration; Nitric Oxide Synthase Type II - biosynthesis; Oxygen - blood; Peroxidase - metabolism; Pulmonary Edema - etiology; Pulmonary Edema - pathology; Pulmonary Surfactants; Rabbits; Respiratory Mechanics - physiology; Studies; Surfactants; Ventilators, Mechanical - adverse effects; Chemokine; Heterogeneity; Lung disease; Vertebrata; Depletion; Mammalia; Respiratory disease; Acute; Inflammation; chemokines; acute lung injury

1 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania; 2 Oscillogy, Folsom, Pennsylvania; 3 Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, and 4 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania,...