Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations

• Published in: NeuroImage (Orlando, Fla.) Vol. 59; no. 4; pp. 3243 - 3251
• Main Authors: Shrestha, Saurav, Hirvonen, Jussi, Hines, Christina S., Henter, Ioline D., Svenningsson, Per, Pike, Victor W., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2012; Elsevier Limited
• Subjects: Anxiety; Blood-brain barrier; Brain research; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - metabolism; Funding; Humans; Major depressive disorder (MDD); Medical imaging; Mental depression; Mental health; Neuroimaging; Permeability-glycoprotein (P-gp); Positron emission tomography (PET); Positron-Emission Tomography; Radioligand; Receptor, Serotonin, 5-HT1A - metabolism; Serotonin; Serotonin-1A (5-HT1A) receptors; Studies; Systematic review; Neuroimaging; Positron emission tomography (PET); Radioligand; Serotonin-1A (5-HT1A) receptors; Permeability-glycoprotein (P-gp); Major depressive disorder (MDD)

The serotonin-1A (5-HT1A) receptor is of particular interest in human positron emission tomography (PET) studies of major depressive disorder (MDD). Of the eight studies investigating this issue in the brains of patients with MDD, four reported decreased 5-HT1A receptor density, two reported no chan...