1866-P: Adipocyte Hypertrophy Is Associated with Increased Dietary Fatty Acid Storage in Adipose Tissue and Reduced Postprandial Hepatic Fatty Acid Uptake and Esterification in Humans

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. Supplement_1
• Main Authors: YE, RUN ZHOU, PHOENIX, SERGE, NOLL, CHRISTOPHE, MONTASTIER, EMILIE, FRISCH, FRÉDÉRIQUE, BOUFFARD, LUCIE, AMRANI, MEHDI, TURCOTTE, ERIC E., CARPENTIER, ANDRÉ C.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2020
• Subjects: Abdomen; Adipocytes; Adipose tissue; Blood glucose; Cell size; Diabetes; Esterification; Fasting; Fatty acids; Fatty liver; Homeostasis; Hypertrophy; Insulin; Insulin resistance; Intravenous administration; Lipolysis; Oral administration; Oxidation; Palmitic acid; Positron emission tomography; Steatosis
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db20-1866-P

Introduction: Excessive exposure of lean tissues to nonesterified fatty acids (NEFA) leads to insulin resistance (IR). Adipocyte hypertrophy is associated with IR and increase in adipose tissue intracellular triglyceride lipolysis and in NEFA levels, that may contribute to hepatic steatosis and IR....