321-OR: Haptoglobin (Hp) Levels and Phenotype Are Unrelated to Severe Retinopathy in Type 2 Diabetes, but Lower Hp Reductions by Fenofibrate Are Associated with Greater Retinopathy Benefit—A FIELD Trial Study

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. Supplement_1; p. 1
• Main Authors: LEUNG ONG, KWOK, JANUSZEWSKI, ANDRZEJ S., FRANCIS, HABIB, MANGANI, ABUBAKAR SIDDIQ O., O'CONNELL, RACHEL L., JENKINS, ALICIA, KEECH, ANTHONY C.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 14.06.2024
• Subjects: Coronary artery; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic retinopathy; Fenofibrate; Genotype & phenotype; Genotypes; Haptoglobin; Kidney diseases; Oxidants; Phenotypes; Retinopathy

Background: The abundant plasma protein Hp has anti-oxidant and anti-inflammatory effects. Its genotype/phenotype modulates chronic diabetes complication risk and fenofibrate benefit on coronary artery and kidney disease in type 2 diabetes (T2D). It is unknown whether Hp phenotype and level are asso...