2102-P: Upregulation of Adipose Tissue APOE Expression by ω3PUFA Supplementation Associates with Decreased Plasma FFA Levels and Improves Insulin Sensitivity in Obese Subjects

• Published in: Diabetes (New York, N.Y.) Vol. 68; no. Supplement_1
• Main Authors: RAU, CASSANDRA, LI, TING, HERNANDEZ, JAMES D., MASUDA, MIA Y., ZHANG, XIAODONG, WANG, PANWEN, COLETTA, DAWN K., DEFILIPPIS, ELEANNA
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2019
• Subjects: Adiponectin; Adipose tissue; Apolipoprotein E; DNA microarrays; Fish oils; Gelatinase B; Gene expression; Inflammation; Insulin; Insulin resistance; Interleukin 1; Leptin; Matrilysin; Obesity; Plasma; Polymerase chain reaction; Supplements

Inflammation of adipose tissue (AT) is key for the development of insulin resistance (IR) in obesity. We previously showed that 3 months supplementation of fish oil (FO, 4g/day), a well-known anti-inflammatory agent, induced 25% improvement in glucose disposal during euglycemic-hyperinsulinemic clam...