Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus - Nakamura, Kazuya; Harada, Yuichi; Takahashi, Hitoshi; Trusheim, Heidi; Bernhard, Roth; Hamamoto, Itsuki; Hirata-Saito, Asumi; Ogane, Teruko; Mizuta, Katsumi; Konomi, Nami; Konomi, Yasushi; Asanuma, Hideki; et al. (Vaccine, 2019)
Keywords: Allergy and Immunology; Amino acid substitution; Amino acids; Antigenicity; Antigens; Binding sites; dogs; Eggs; Exo-a-sialidase; genes; Genetic and antigenic stability; genetic stability; Glycosylation; HA protein; Health care; hemagglutination; Hemagglutination inhibition; Hemagglutinins; hens; humans; Illnesses; Infections; Influenza; Influenza A virus; Influenza vaccine seed virus; influenza vaccines; Kidneys; Macaca mulatta; Madin–Darby canine kidney cell line; Mutation; Pandemics; sialidase; Stability; Suspension culture; Vaccines; virus replication; Viruses; United States--US; Japan; HI; Suspension culture; MDCK-N; NA; MDCK cells; EID50; Madin–Darby canine kidney cell line; MDCK-C; Influenza vaccine seed virus; Genetic and antigenic stability; HA; LLC-MK2D; adherent MDCK cells; hemagglutination inhibition; 50% egg infectious dose; hemagglutinin; Madin–Darby canine kidney cells; adherent LLC-MK2 cells; neuraminidase; suspension MDCK cells; EID 50