Mucosal Epithelial Jak Kinases in Health and Diseases

• Published in: Mediators of inflammation Vol. 2021; pp. 1 - 17
• Main Authors: Kumar, Narendra, Kuang, Longxiang, Villa, Ryan, Kumar, Priyam, Mishra, Jayshree
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc; Wiley
• Subjects: Animals; Apoptosis; B cells; Cell adhesion & migration; Cell differentiation; Cell growth; Cell survival; Cellular signal transduction; Cytokines; Disease; Drug approval; Epithelial cells; Graft rejection; Growth factors; Homeostasis; Human subjects; Humans; Immunosuppressive agents; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory diseases; Intestine; Irritable bowel syndrome; Janus kinase; Janus kinase 2; Janus Kinases - metabolism; Kinases; Mesenchyme; Metabolic syndrome; Mice; Mucosa; Mutation; Physiological aspects; Protein-tyrosine kinase; Psoriasis; Review; Rheumatoid arthritis; Rheumatoid factor; Roles; Severe combined immunodeficiency; Signal Transduction; Stem cells; Therapeutic applications; Tumor necrosis factor-TNF; TYK2 Kinase - metabolism; Tyk2 protein; Tyrosine; Wound healing

Janus kinases (Jaks) are a family of nonreceptor tyrosine kinase that include four different members, viz., Jak1, Jak2, Jak3, and Tyk2. Jaks play critical roles in immune cells functions; however, recent studies suggest they also play essential roles in nonimmune cell physiology. This review highlig...