Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice

• Published in: Molecular metabolism (Germany) Vol. 6; no. 7; pp. 760 - 769
• Main Authors: Seshadri, Nivedita, Jonasson, Michael E., Hunt, Kristin L., Xiang, Bo, Cooper, Steven, Wheeler, Michael B., Dolinsky, Vernon W., Doucette, Christine A.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.07.2017; Elsevier
• Subjects: Brief Communication; Glucose tolerance; Glucose-stimulated insulin secretion; Pancreatic islets; Uncoupling protein 2; β cells; MIN6; β cells; T2D; i.p.GTT; Glucose tolerance; Uncoupling protein 2; UCP2; GSIS; Ucp2-βKO; Glucose-stimulated insulin secretion; Pancreatic islets; ZT; Ins2-cre; LG; WT; HG; ZT, Zeitgeber time; GSIS, Glucose-stimulated insulin secretion; WT, wild type; LG, Low glucose; HG, High glucose; Ins2-cre, Ins2 promoter-driven cre recombinase; MIN6, Mouse insulinoma 6; T2D, Type 2 diabetes; i.p.GTT, intraperitoneal glucose tolerance test; UCP2, Uncoupling protein 2; Ucp2-βKO, β cell-specific Ucp2 knockout

Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); however, the physiological function of UCP2 in the β cell remains...