Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring

• Published in: BIOLOGICAL PSYCHIATRY Vol. 70; no. 8; pp. 763 - 769
• Main Authors: DiNieri, Jennifer A., Wang, Xinyu, Szutorisz, Henrietta, Spano, Sabrina M., Kaur, Jasbir, Casaccia, Patrizia, Dow-Edwards, Diana, Hurd, Yasmin L.
• Format: Journal Article Publication
• Language: English
• Published: New York, NY Elsevier Inc 15.10.2011; Elsevier
• Subjects: Addiction; Alcohol Drinking - genetics; Animals; Animals, Newborn; Biological and medical sciences; Conditioning, Psychological - drug effects; D1 receptor; development; Dronabinol - adverse effects; dynorphin; enkephalin; Enkephalins - biosynthesis; Epigenesis, Genetic - drug effects; Female; Fetus - drug effects; Fetus - metabolism; Gene Expression Regulation, Developmental - drug effects; Humans; Male; Marijuana Abuse - diagnostic imaging; Marijuana Abuse - genetics; Medical sciences; Morphine - pharmacology; Nucleus Accumbens - diagnostic imaging; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Pregnancy; Prenatal Exposure Delayed Effects - diagnostic imaging; Prenatal Exposure Delayed Effects - genetics; Prenatal Exposure Delayed Effects - psychology; Protein Precursors - biosynthesis; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radioligand Assay - methods; Radionuclide Imaging; Rats; Rats, Long-Evans; Receptors, Dopamine D2 - biosynthesis; Receptors, Dopamine D2 - genetics; Reward; Smoking - genetics; THC; enkephalin; development; dynorphin; Addiction; D1 receptor; THC; Central nervous system; Enkephalin; Cannabidaceae; Genetic determinism; Neuropeptide; Opioid peptide; Encephalon; Cannabis; Gene; Dicotyledones; Angiospermae; Development; Genetics; Drug of abuse; Dopamine; D1 Dopamine receptor; Basal ganglion; Corpus striatum; Catecholamine; Progeny; Dynorphin; Neurotransmitter; Spermatophyta; Recreational drug

Prenatal cannabis exposure has been linked to addiction vulnerability, but the neurobiology underlying this risk is unknown. Striatal dopamine and opioid-related genes were studied in human fetal subjects exposed to cannabis (as well as cigarettes and alcohol). Cannabis-related gene disturbances obs...