Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation

• Published in: Thrombosis and haemostasis Vol. 111; no. 4; p. 590
• Main Authors: Langer, Florian, Ruf, Wolfram
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2014
• Subjects: Animals; Antilymphocyte Serum - metabolism; Blood Coagulation - drug effects; Carboxy-Lyases - metabolism; Complement Activation; Drug Synergism; Humans; Inflammation - blood; Myeloid Cells - metabolism; Myocytes, Smooth Muscle - metabolism; Protein Disulfide-Isomerases - metabolism; Receptors, Purinergic P2X7 - metabolism; Thromboplastin - metabolism; Thrombosis - blood; phosphatidylserine; thrombosis; thiol-disulfide exchange; protein disulfide isomerase; Tissue factor

Tissue factor (TF), the cellular receptor and cofactor for factor VII/VIIa, initiates haemostasis and thrombosis. Initial tissue distribution studies suggested that TF was sequestered from the circulation and only present at perivascular sites. However, there is now clear evidence that TF also exist...