Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis

• Published in: Mediators of inflammation Vol. 2021; pp. 6259381 - 12
• Main Authors: Sun, Qian, Ji, Yan-Chun, Wang, Zheng-Li, She, Xiang, He, Yu, Ai, Qing, Li, Lu-Quan
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Animals; Antigens; Body weight; Butyric Acid - pharmacology; Butyric Acid - therapeutic use; Chromosomal proteins; Disease Models, Animal; Enterocolitis; Enterocolitis, Necrotizing - drug therapy; Enterocolitis, Necrotizing - immunology; Enterocolitis, Necrotizing - pathology; Enterocolitis, Neonatal necrotizing; Enterocolitis, Pseudomembranous; Esters; Feces; Female; Gastrointestinal diseases; Gene expression; HMGB1 protein; HMGB1 Protein - genetics; HMGB1 Protein - physiology; Hypoxia; Inflammation; Interleukin 10; Interleukin 6; Interleukin 8; Interleukins; Intestinal microflora; Intestine; Intestines - microbiology; Intestines - pathology; Male; Medical prognosis; Mice; Mice, Inbred C57BL; Microbiota; Microbiota (Symbiotic organisms); Necrosis; Necrotizing enterocolitis; Neonates; NF-kappa B - genetics; NF-kappa B - physiology; NF-κB protein; Random Allocation; RNA; Small intestine; Sodium; Sodium butyrate; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - physiology; Toll-like receptors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; China; United States > US; Japan

Objective. To determine the role of sodium butyrate in intestinal inflammation via regulation of high-mobility group box-1 (HMGB1), we analyzed the potential mechanism in necrotizing enterocolitis (NEC) in a neonatal mouse model. Methods. A NEC model was created with hypoxia and cold exposure and ar...