Is SIRT2 required for necroptosis?

• Published in: Nature (London) Vol. 506; no. 7489; pp. E4 - E6
• Main Authors: Newton, Kim, Hildebrand, Joanne M., Shen, Zhirong, Rodriguez, Diego, Alvarez-Diaz, Silvia, Petersen, Sean, Shah, Saumil, Dugger, Debra L., Huang, Chunzi, Auwerx, Johan, Vandenabeele, Peter, Green, Douglas R., Ashkenazi, Avi, Dixit, Vishva M., Kaiser, William J., Strasser, Andreas, Degterev, Alexei, Silke, John
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.02.2014; Nature Publishing Group
• Subjects: 631/80/82/2344; Animals; Apoptosis; Body temperature; brief-communications-arising; Cell death; Cell physiology; Cell research; Enzymes; Experiments; Female; Humanities and Social Sciences; Humans; Male; multidisciplinary; Necrosis - enzymology; Regulation; Rodents; Science; Sirtuin 2 - genetics; Sirtuin 2 - metabolism

Arising from N. Narayan et al. Nature492, 199–204 (2012)10.1038/nature11700 Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments to regulate many cellular processes 1 , 2 ; recently, Narayan et al. 3 reported that SIRT2 was required for necroptosis on the...