Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi

• Published in: Molecular metabolism (Germany) Vol. 20; pp. 128 - 137
• Main Authors: Xiong, Xuelian, Wang, Qiuyu, Wang, Shuai, Zhang, Jinglong, Liu, Tongyu, Guo, Liang, Yu, Yonghao, Lin, Jiandie D.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.02.2019; Elsevier
• Subjects: Animals; Diet, High-Fat - adverse effects; Hepatokine; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; NAFLD; NASH; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - metabolism; Original; Proteoglycans - genetics; Proteoglycans - metabolism; Proteome - genetics; Proteome - metabolism; Proteomics; Secreted factor; Transcriptome; TSK; Type I interferon; NAS; NAFLD; AST; KO; Transcriptome; HFD; ALT; WAT; NASH; TSK; MCD; IFN; Type I interferon; Hepatokine; Proteomics; qPCR; TAG; Secreted factor; WT
• ISSN: 2212-8778; 2212-8778
• DOI: 10.1016/j.molmet.2018.12.004

Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. The objectives of the cu...