Cytokines in bipolar disorder vs. healthy control subjects: A systematic review and meta-analysis

• Published in: Journal of psychiatric research Vol. 47; no. 9; pp. 1119 - 1133
• Main Authors: Munkholm, Klaus, Braüner, Julie Vestergaard, Kessing, Lars Vedel, Vinberg, Maj
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Affect; Biological and medical sciences; Biomarker; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - metabolism; Bipolar disorders; Cell death; Cytokines; Databases, Factual; Dysfunction; Heterogeneity; Humans; Inflammation; Medical sciences; Meta-analysis; Mood disorders; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Review; Tumours; Bipolar disorder; Biomarker; Inflammation; Review; Cytokines; Meta-analysis; Mood disorder; Human; Healthy subject; Cytokine; Biological marker; Metaanalysis
• ISSN: 0022-3956; 1879-1379; 1879-1379
• DOI: 10.1016/j.jpsychires.2013.05.018

Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states. We conducted...