Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect

• Published in: Oncogene Vol. 34; no. 32; pp. 4229 - 4237
• Main Authors: Xu, Y, Miriyala, S, Fang, F, Bakthavatchalu, V, Noel, T, Schell, D M, Wang, C, St Clair, W H, St Clair, D K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.08.2015; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/1; 13/106; 13/109; 13/31; 13/89; 13/95; 38/39; 38/61; 38/77; 631/67/2327; 64/60; Adenosine Triphosphate - metabolism; AKT protein; Animals; Antioxidants; Apoptosis; Blotting, Western; Cancer; Carcinogenesis; Cell Biology; Cells, Cultured; Enzymes; Genetic aspects; Glycolysis; Human Genetics; Humans; Internal Medicine; Ion Channels - genetics; Ion Channels - metabolism; Lactates - metabolism; Lactic acid; Manganese; Medicine; Medicine & Public Health; Mice, Knockout; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial diseases; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Oncology; original-article; Oxidation; Phosphatidylinositol 3-Kinases - metabolism; Physiological aspects; PPAR alpha - genetics; PPAR alpha - metabolism; Protein expression; Proto-Oncogene Proteins c-akt - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; RNA Interference; Signal transduction; Signal Transduction - genetics; Superoxide dismutase; Superoxide Dismutase - deficiency; Superoxide Dismutase - genetics; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumorigenesis; Uncoupling Protein 1; Uncoupling Protein 2; United States

Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life and to have important roles in tumorigenesis. Here, we show that MnSOD deficiency in skin tissues of MnSOD-heterozygous knockout ( Sod2 +/− ) mice...