Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGlu...
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| Published in | Cellular and molecular life sciences : CMLS Vol. 65; no. 18; pp. 2913 - 2923 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
Basel : SP Birkhäuser Verlag Basel
01.09.2008
SP Birkhäuser Verlag Basel Springer Nature B.V |
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| Abstract | Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity. |
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| AbstractList | .
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity. Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity. Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity. [PUBLICATION ABSTRACT] Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity. |
| Author | Lüscher, C Bellone, C Mameli, M |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18712277$$D View this record in MEDLINE/PubMed |
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| Copyright | Birkhaueser 2008 Copyright Springer Nature B.V. Sep 2008 |
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| Snippet | Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity... . Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic... |
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| SubjectTerms | AMPA receptors Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Excitatory Postsynaptic Potentials Excitatory Postsynaptic Potentials - physiology glutamic acid Glutamic acid receptors (metabotropic) Humans Life Sciences loci Long-term depression Long-Term Synaptic Depression Long-Term Synaptic Depression - physiology Mental depression metabolism metabotropic glutamate receptors Molecular biology Neuronal Plasticity Neuronal Plasticity - physiology Neurons physiology Protein Isoforms Protein Isoforms - metabolism Receptors Receptors, Metabotropic Glutamate Receptors, Metabotropic Glutamate - metabolism Review Signal transduction Synapses Synapses - physiology Synaptic depression Synaptic plasticity Synaptic strength Synaptic Transmission Synaptic Transmission - physiology |
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| Title | Mechanisms of synaptic depression triggered by metabotropic glutamate receptors |
| URI | https://link.springer.com/article/10.1007/s00018-008-8263-3 https://www.ncbi.nlm.nih.gov/pubmed/18712277 https://www.proquest.com/docview/213514218 https://www.proquest.com/docview/3195146222 https://www.proquest.com/docview/19366059 https://www.proquest.com/docview/48084256 https://www.proquest.com/docview/69589744 https://pubmed.ncbi.nlm.nih.gov/PMC11131865 |
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