Cell cycle regulation of chromatin at an origin of DNA replication

• Published in: The EMBO journal Vol. 24; no. 7; pp. 1406 - 1417
• Main Authors: Zhou, Jing, Chau, Charles M, Deng, Zhong, Shiekhattar, Ramin, Spindler, Mark-Peter, Schepers, Aloys, Lieberman, Paul M
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 06.04.2005; Nature Publishing Group UK; Springer Nature B.V
• Subjects: Adenosine Triphosphatases - metabolism; ATP; Cell Cycle - physiology; Cells, Cultured; Chromatin Assembly and Disassembly - physiology; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone - metabolism; Deoxyribonucleic acid; DNA; DNA Replication; EBV; EMBO09; EMBO13; Epigenesis, Genetic - physiology; Epstein-Barr virus; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - physiology; histone; Histone Deacetylase 1; Histone Deacetylases - metabolism; Histones - metabolism; Humans; Licensing; Macromolecular Substances - metabolism; Mammals; Models, Biological; Nucleosomes - metabolism; OriP; Plasmids - genetics; Replication Origin - genetics; Replication Origin - physiology; RNA, Small Interfering - metabolism; SNF2h; EBV; DNA replication; histone; SNF2h; OriP

Selection and licensing of mammalian DNA replication origins may be regulated by epigenetic changes in chromatin structure. The Epstein–Barr virus (EBV) origin of plasmid replication ( OriP ) uses the cellular licensing machinery to regulate replication during latent infection of human cells. We fou...