RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex

• Published in: EMBO reports Vol. 8; no. 8; pp. 763 - 769
• Main Authors: Kawahara, Yukio, Zinshteyn, Boris, Chendrimada, Thimmaiah P, Shiekhattar, Ramin, Nishikura, Kazuko
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2007; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: ADAR; Adenosine Deaminase - genetics; Animals; Base Sequence; Brain - metabolism; Dicer; EMBO36; Genetics; Humans; Mice; Mice, Mutant Strains; microRNA; MicroRNAs - chemistry; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular biology; Molecular Sequence Data; Nucleic Acid Conformation; Ribonuclease III - chemistry; Ribonuclease III - metabolism; Ribonucleic acid; RNA; RNA Editing; RNA interference; RNA Precursors - chemistry; RNA Precursors - metabolism; RNA-Binding Proteins; Scientific Report; Scientific Reports; microRNA; RNA editing; ADAR; RNA interference; Dicer

MicroRNAs (miRNAs) mediate translational repression or degradation of their target messenger RNAs by RNA interference (RNAi). The primary transcripts of miRNA genes (pri‐miRNAs) are sequentially processed by the nuclear Drosha–DGCR8 complex to approximately 60–70 nucleotide (nt) intermediates (pre‐m...