Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion

• Published in: Biological psychiatry (1969) Vol. 79; no. 11; pp. 906 - 916
• Main Authors: Kibaly, Cherkaouia, Kam, Angel Y.F., Loh, Horace H., Law, Ping-Yee
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: AMPA receptors; Animals; Cells, Cultured; Extinction, Psychological - drug effects; Extinction, Psychological - physiology; GluA1; GluA1-S845; GluA1-S845A mutant; Hippocampus - drug effects; Hippocampus - metabolism; Maze Learning - drug effects; Maze Learning - physiology; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; Phosphorylation - drug effects; Post-Synaptic Density - drug effects; Post-Synaptic Density - metabolism; Psychiatric/Mental Health; Rats, Sprague-Dawley; Receptors, AMPA - genetics; Receptors, AMPA - metabolism; Receptors, Opioid, mu - genetics; Receptors, Opioid, mu - metabolism; Spatial memory; Spatial Memory - drug effects; Spatial Memory - physiology; GluA1-S845A mutant; GluA1-S845; AMPA receptors; GluA1; Naltrexone; Spatial memory

The opioid antagonists naloxone/naltrexone are involved in improving learning and memory, but their cellular and molecular mechanisms remain unknown. We investigated the effect of naloxone/naltrexone on hippocampal α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) trafficking, a...