Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 9; pp. 3466 - 3471
• Main Authors: Soroceanu, Liliana, Kharbanda, Samir, Chen, Ruihuan, Soriano, Robert H, Aldape, Ken, Misra, Anjan, Zha, Jiping, Forrest, William F, Nigro, Janice M, Modrusan, Zora, Feuerstein, Burt G, Phillips, Heidi S
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.02.2007; National Acad Sciences
• Subjects: Antibodies; Biological Sciences; Blotting, Western; Brain; carcinogenesis; Cell growth; Cell lines; Cell Proliferation; Comparative genomic hybridization; epidermal growth factor receptors; Gene Expression Profiling; gene overexpression; Genetic markers; Glioblastoma - metabolism; Glioblastoma - physiopathology; Glioma; Growth factors; Humans; Immunoprecipitation; In Situ Hybridization; Insulin; insulin-like growth factor I receptor; Insulin-Like Growth Factor II; Kinases; Messenger RNA; neoplasms; Neurons; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - metabolism; Proteins - metabolism; Receptors; Receptors, Somatomedin - metabolism; Signal amplification; Signal Transduction - physiology; stem cells; Tumors

Amplification or overexpression of growth factor receptors is a frequent occurrence in malignant gliomas. Using both expression profiling and in situ hybridization, we identified insulin-like growth factor 2 (IGF2) as a marker for a subset of glioblastomas (GBMs) that lack amplification or overexpre...