Pierisin, Cytotoxic and Apoptosis-Inducing DNA ADP-Ribosylating Protein in Cabbage Butterfly

• Published in: Toxins Vol. 16; no. 6; p. 270
• Main Authors: Takahashi-Nakaguchi, Azusa, Horiuchi, Yu, Yamamoto, Masafumi, Totsuka, Yukari, Wakabayashi, Keiji
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.06.2024; MDPI
• Subjects: Adenosine diphosphate; ADP Ribose Transferases - genetics; ADP Ribose Transferases - metabolism; Amino acids; Animals; Antineoplastic Agents - pharmacology; Antitumor activity; Apoptosis; Apoptosis - drug effects; Biotechnology; Botulinum toxin; Butterflies; Butterflies & moths; Cancer; Causes of; Cell surface; Cells; Cloning; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA ADP-ribosylation; DNA damage; Glycosphingolipids; Health aspects; Hormones; Humans; Insect Proteins - chemistry; Insect Proteins - metabolism; Medical research; Medicine; Metamorphosis; Microorganisms; Molecular biology; Mutation; Physiological aspects; Pieris rapae; Pierisin-1; Proteins; R; Radioactivity; Review; Therapeutic applications; Toxins; Tumor cell lines; Japan; DNA ADP-ribosylation; Pierisin-1; Pieris rapae

Pierisin-1 was serendipitously discovered as a strong cytotoxic and apoptosis-inducing protein from pupae of the cabbage butterfly Pieris rapae against cancer cell lines. This 98-kDa protein consists of the N-terminal region (27 kDa) and C-terminal region (71 kDa), and analysis of their biological f...