Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells - Zhou, Shu-Feng; Wang, Yan-Yang; Yang, Yin-Xue; He, Zhixue; Zhao, Ren; Hong, Zhe; Zhang, Xueji; Pan, Shuting; Duan, Wei; Yang, Tianxin; Qiu, Jiaxuan (Drug design, development and therapy, 2015)
Keywords: 1-Phosphatidylinositol 3-kinase; Acids; Akt; AKT protein; Anticancer properties; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; B-cell lymphoma; Bax protein; Bcl-2 protein; Bcl-x protein; Bmi protein; Cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Care and treatment; Caspase-9; CDDO-Me; cell cycle; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemotherapy; Cyclin-dependent kinase inhibitor p21; Cyclin-dependent kinases; Diabetes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; E-cadherin; EMT; Epithelial-Mesenchymal Transition - drug effects; Esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma; Esophagus; Health aspects; Homeobox; Homology; Humans; Kidney diseases; Kinases; Lymphocytes B; Lymphoma; Mesenchyme; mTOR; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - pathology; Nuclear engineering; Nuclear safety; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - pharmacology; Original Research; Oxidative stress; p53 Protein; Patients; Phagocytosis; Poly(ADP-ribose) polymerase; Proteins; Rapamycin; Reactive oxygen species; Ribose; Signal transduction; Squamous cell carcinoma; stemness; Structure-Activity Relationship; Terpenoids; Tumor Cells, Cultured; Womens health; Zinc finger proteins; United States--US; China; Africa; esophageal squamous cell carcinoma; autophagy; CDDO-Me; cell cycle; stemness; mTOR; apoptosis; Akt; EMT