Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans

• Published in: International Journal of Obesity Vol. 40; no. 11; pp. 1655 - 1661
• Main Authors: Hibi, M, Oishi, S, Matsushita, M, Yoneshiro, T, Yamaguchi, T, Usui, C, Yasunaga, K, Katsuragi, Y, Kubota, K, Tanaka, S, Saito, M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2016; Nature Publishing Group
• Subjects: 59/78; 631/443/319; 631/443/319/333/1465; 631/57/2272/951; 692/700/2814; Adipose tissue; Adipose Tissue, Brown - diagnostic imaging; Adipose Tissue, Brown - metabolism; Adult; Asian Continental Ancestry Group; Body fat; Body mass index; Cold; Cold Temperature; Computed tomography; Cross-Sectional Studies; Diabetes; Diet; Energy; Energy Intake - physiology; Energy Metabolism - physiology; Epidemiology; Fatty acids; Fluorodeoxyglucose F18 - therapeutic use; Glucose; Health aspects; Health Promotion and Disease Prevention; Healthy Volunteers; Humans; Internal Medicine; Japan; Laboratories; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Metabolites; Middle Aged; Nutrition research; Obesity; Original; original-article; Oxidation; Physiological aspects; Positron emission tomography; Positron Emission Tomography Computed Tomography; Public Health; Radiopharmaceuticals - therapeutic use; Thermogenesis; Thermogenesis - physiology; Tomography; United States > US; Japan

Background/Objectives: Brown adipose tissue (BAT) is a potential therapeutic target against obesity and diabetes through thermogenesis and substrate disposal with cold exposure. The role of BAT in energy metabolism under thermoneutral conditions, however, remains controversial. We assessed the contr...