Enhanced platelet aggregation and activation under conditions of hypothermia

• Published in: Thrombosis and haemostasis Vol. 98; no. 6; p. 1266
• Main Authors: Xavier, Ruben G, White, Ann E, Fox, Susan C, Wilcox, Robert G, Heptinstall, Stan
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2007
• Subjects: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology; Adenosine Diphosphate - metabolism; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - pharmacology; Anticoagulants - pharmacology; Antigens, CD - metabolism; Aspirin - pharmacology; Blood Platelets - drug effects; Blood Platelets - immunology; Blood Platelets - metabolism; Blood Specimen Collection - methods; Citrates - pharmacology; Cold Temperature; Cyclooxygenase Inhibitors - pharmacology; Dose-Response Relationship, Drug; Hirudins - pharmacology; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin - metabolism; Platelet Activating Factor - metabolism; Platelet Activation - drug effects; Platelet Aggregation - drug effects; Platelet Function Tests; Platelet Membrane Glycoproteins - metabolism; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - metabolism; Receptors, Purinergic P2Y12; Receptors, Thrombin - metabolism; Tetraspanin 30; Time Factors

The effects on platelet function of temperatures attained during hypothermia used in cardiac surgery are controversial. Here we have performed studies on platelet aggregation in whole blood and platelet-rich plasma after stimulation with a range of concentrations of ADP, TRAP, U46619 and PAF at both...