Human polymorphism at microRNAs and microRNA target sites

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 9; pp. 3300 - 3305
• Main Authors: Saunders, Matthew A, Liang, Han, Li, Wen-Hsiung
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.02.2007; National Acad Sciences
• Subjects: Biological Sciences; Computational Biology; Evolution; Genes; Genome, Human - genetics; Genomes; Genotype & phenotype; Haplotypes; Humans; Messenger RNA; MicroRNA; MicroRNAs - genetics; Nucleotides; Polymorphism, Single Nucleotide - genetics; Population genetics; Positive selection; Ribonucleic acid; RNA; Selection, Genetic; single nucleotide polymorphism; translation (genetics); Untranslated regions

MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in animals by binding to target sites in the 3' UTRs of mRNAs. Because a single nucleotide change in the sequence of a target site can affect miRNA regulation, naturally occurring SNPs in target sites are...