Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

• Published in: Neuron (Cambridge, Mass.) Vol. 40; no. 6; pp. 1251 - 1257
• Main Authors: Jensen, Jimmy, McIntosh, Anthony R, Crawley, Adrian P, Mikulis, David J, Remington, Gary, Kapur, Shitij
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.12.2003; Elsevier Limited
• Subjects: Adult; Animal behavior; Avoidance Learning - physiology; Basal Ganglia - physiology; Basic Medicine; Brain; Dopamine; Electric Stimulation - methods; Experiments; Female; Humans; Magnetic Resonance Imaging - methods; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Neurosciences; Neurovetenskaper; Pain; Pain Measurement - methods; Reward

The brain “reward” system, centered on the limbic ventral striatum, plays a critical role in the response to pleasure and pain. The ventral striatum is activated in animal and human studies during anticipation of appetitive/pleasurable events, but its role in aversive/painful events is less clear. H...