Network Effects of the 15q13.3 Microdeletion on the Transcriptome and Epigenome in Human-Induced Neurons

• Published in: Biological psychiatry (1969) Vol. 89; no. 5; pp. 497 - 509
• Main Authors: Zhang, Siming, Zhang, Xianglong, Purmann, Carolin, Ma, Shining, Shrestha, Anima, Davis, Kasey N., Ho, Marcus, Huang, Yiling, Pattni, Reenal, Wong, Wing Hung, Bernstein, Jonathan A., Hallmayer, Joachim, Urban, Alexander E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021
• Subjects: 15q13.3; Chromosome Deletion; Chromosome Disorders - genetics; Chromosomes, Human, Pair 15 - genetics; Copy number variants; CRISPR–Cas9; Epigenome; Genomics; Humans; Induced pluripotent stem cells; Intellectual Disability; Neurons; Psychiatric/Mental Health; Seizures; Transcriptome; 15q13.3; Induced pluripotent stem cells; Neurons; CRISPR–Cas9; Genomics; Copy number variants

The 15q13.3 microdeletion is associated with several neuropsychiatric disorders, including autism and schizophrenia. Previous association and functional studies have investigated the potential role of several genes within the deletion in neuronal dysfunction, but the molecular effects of the deletio...