Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models

• Published in: The Journal of clinical investigation Vol. 130; no. 2; pp. 904 - 920
• Main Authors: Song, Bin, Cha, Young, Ko, Sanghyeok, Jeon, Jeha, Lee, Nayeon, Seo, Hyemyung, Park, Kyung-Joon, Lee, In-Hee, Lopes, Claudia, Feitosa, Melissa, Luna, María José, Jung, Jin Hyuk, Kim, Jisun, Hwang, Dabin, Cohen, Bruce M, Teicher, Martin H, Leblanc, Pierre, Carter, Bob S, Kordower, Jeffrey H, Bolshakov, Vadim Y, Kong, Sek Won, Schweitzer, Jeffrey S, Kim, Kwang-Soo
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.02.2020
• Subjects: Animal models; Autografts; Backup software; Biomedical research; Cell culture; Cell therapy; Diseases; Dopamine; Dopamine receptors; Fibroblasts; Gene expression; Health aspects; Inhibitory postsynaptic potentials; Mesencephalon; Metabolism; MicroRNA; MicroRNAs; miRNA; Morphology; Movement disorders; Mutation; Neostriatum; Neurodegeneration; Neurodegenerative diseases; Neurons; Parkinson disease; Parkinson's disease; Phenols (Class of compounds); Pluripotency; Quality; Recovery of function; Respiration; Stem cell transplantation; Stem cells; Substantia nigra; Surgery; Transplantation; Tumors; Stem cell transplantation; Neuroscience; Parkinson’s disease; Stem cells

Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. To establish human induced pluripotent stem...