BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers
BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) demonstrates nonspecific, protective inn...
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Published in | The Journal of clinical investigation Vol. 131; no. 2; pp. 1 - 11 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
American Society for Clinical Investigation
19.01.2021
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Abstract | BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) demonstrates nonspecific, protective innate immune-boosting effects. Here, we determined whether a history of BCG vaccination was associated with decreased SARS-CoV-2 infection and seroconversion in a longitudinal, retrospective observational study of a diverse cohort of health care workers (HCWs).METHODSWe assessed SARS-CoV-2 seroprevalence and collected medical questionnaires, which included information on BCG vaccination status and preexisting demographic and clinical characteristics, from an observational cohort of HCWs in a multisite Los Angeles health care organization. We used multivariate analysis to determine whether a history of BCG vaccination was associated with decreased rates of SARS-CoV-2 infection and seroconversion.RESULTSOf the 6201 HCWs, 29.6% reported a history of BCG vaccination, whereas 68.9% had not received BCG vaccination. Seroprevalence of anti-SARS-CoV-2 IgG as well as the incidence of self-reported clinical symptoms associated with coronavirus disease 2019 (COVID-19) were markedly decreased among HCWs with a history of BCG vaccination compared with those without BCG vaccination. After adjusting for age and sex, we found that a history of BCG vaccination, but not meningococcal, pneumococcal, or influenza vaccination, was associated with decreased SARS-CoV-2 IgG seroconversion.CONCLUSIONSA history of BCG vaccination was associated with a decrease in the seroprevalence of anti-SARS-CoV-2 IgG and a lower number of participants who self-reported experiencing COVID-19-related clinical symptoms in this cohort of HCWs. Therefore, large randomized, prospective clinical trials of BCG vaccination are urgently needed to confirm whether BCG vaccination can confer a protective effect against SARS-CoV-2 infection. |
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AbstractList | BACKGROUND. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guerin (BCG) demonstrates nonspecific, protective innate immune-boosting effects. Here, we determined whether a history of BCG vaccination was associated with decreased SARS-CoV-2 infection and seroconversion in a longitudinal, retrospective observational study of a diverse cohort of health care workers (HCWs). METHODS. We assessed SARS-CoV-2 seroprevalence and collected medical questionnaires, which included information on BCG vaccination status and preexisting demographic and clinical characteristics, from an observational cohort of HCWs in a multisite Los Angeles health care organization. We used multivariate analysis to determine whether a history of BCG vaccination was associated with decreased rates of SARS-CoV-2 infection and seroconversion. RESULTS. Of the 6201 HCWs, 29.6% reported a history of BCG vaccination, whereas 68.9% had not received BCG vaccination. Seroprevalence of anti-SARS-CoV-2 IgG as well as the incidence of self-reported clinical symptoms associated with coronavirus disease 2019 (COVID-19) were markedly decreased among HCWs with a history of BCG vaccination compared with those without BCG vaccination. After adjusting for age and sex, we found that a history of BCG vaccination, but not meningococcal, pneumococcal, or influenza vaccination, was associated with decreased SARS-CoV-2 IgG seroconversion. CONCLUSIONS. A history of BCG vaccination was associated with a decrease in the seroprevalence of anti-SARS-CoV-2 IgG and a lower number of participants who self-reported experiencing COVID-19-related clinical symptoms in this cohort of HCWs. Therefore, large randomized, prospective clinical trials of BCG vaccination are urgently needed to confirm whether BCG vaccination can confer a protective effect against SARS-CoV-2 infection. BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) demonstrates nonspecific, protective innate immune-boosting effects. Here, we determined whether a history of BCG vaccination was associated with decreased SARS-CoV-2 infection and seroconversion in a longitudinal, retrospective observational study of a diverse cohort of health care workers (HCWs).METHODSWe assessed SARS-CoV-2 seroprevalence and collected medical questionnaires, which included information on BCG vaccination status and preexisting demographic and clinical characteristics, from an observational cohort of HCWs in a multisite Los Angeles health care organization. We used multivariate analysis to determine whether a history of BCG vaccination was associated with decreased rates of SARS-CoV-2 infection and seroconversion.RESULTSOf the 6201 HCWs, 29.6% reported a history of BCG vaccination, whereas 68.9% had not received BCG vaccination. Seroprevalence of anti-SARS-CoV-2 IgG as well as the incidence of self-reported clinical symptoms associated with coronavirus disease 2019 (COVID-19) were markedly decreased among HCWs with a history of BCG vaccination compared with those without BCG vaccination. After adjusting for age and sex, we found that a history of BCG vaccination, but not meningococcal, pneumococcal, or influenza vaccination, was associated with decreased SARS-CoV-2 IgG seroconversion.CONCLUSIONSA history of BCG vaccination was associated with a decrease in the seroprevalence of anti-SARS-CoV-2 IgG and a lower number of participants who self-reported experiencing COVID-19-related clinical symptoms in this cohort of HCWs. Therefore, large randomized, prospective clinical trials of BCG vaccination are urgently needed to confirm whether BCG vaccination can confer a protective effect against SARS-CoV-2 infection. BACKGROUND. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) demonstrates nonspecific, protective innate immune-boosting effects. Here, we determined whether a history of BCG vaccination was associated with decreased SARS-CoV-2 infection and seroconversion in a longitudinal, retrospective observational study of a diverse cohort of health care workers (HCWs). METHODS. We assessed SARS-CoV-2 seroprevalence and collected medical questionnaires, which included information on BCG vaccination status and preexisting demographic and clinical characteristics, from an observational cohort of HCWs in a multisite Los Angeles health care organization. We used multivariate analysis to determine whether a history of BCG vaccination was associated with decreased rates of SARS-CoV-2 infection and seroconversion. RESULTS. Of the 6201 HCWs, 29.6% reported a history of BCG vaccination, whereas 68.9% had not received BCG vaccination. Seroprevalence of anti-SARS-CoV-2 IgG as well as the incidence of self-reported clinical symptoms associated with coronavirus disease 2019 (COVID-19) were markedly decreased among HCWs with a history of BCG vaccination compared with those without BCG vaccination. After adjusting for age and sex, we found that a history of BCG vaccination, but not meningococcal, pneumococcal, or influenza vaccination, was associated with decreased SARS-CoV-2 IgG seroconversion. CONCLUSIONS. A history of BCG vaccination was associated with a decrease in the seroprevalence of anti-SARS-CoV-2 IgG and a lower number of participants who self-reported experiencing COVID-19-related clinical symptoms in this cohort of HCWs. Therefore, large randomized, prospective clinical trials of BCG vaccination are urgently needed to confirm whether BCG vaccination can confer a protective effect against SARS-CoV-2 infection. |
Audience | Academic |
Author | Wu, Min Sobhani, Kimia Van Eyk, Jennifer E Rivas, Magali Noval Ebinger, Joseph E Cheng, Susan Sun, Nancy Braun, Jonathan Arditi, Moshe |
AuthorAffiliation | 3 Department of Cardiology 8 Barbra Streisand Women’s Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA 4 Smidt Heart Institute 5 F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute 1 Department of Pediatrics, Division of Infectious Diseases and Immunology, Infectious and Immunologic Diseases Research Center (IIDRC), and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA 6 Pathology and Laboratory Medicine 2 Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA 7 Advanced Clinical Biosystems Institute, and |
AuthorAffiliation_xml | – name: 6 Pathology and Laboratory Medicine – name: 7 Advanced Clinical Biosystems Institute, and – name: 2 Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA – name: 8 Barbra Streisand Women’s Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA – name: 4 Smidt Heart Institute – name: 1 Department of Pediatrics, Division of Infectious Diseases and Immunology, Infectious and Immunologic Diseases Research Center (IIDRC), and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA – name: 3 Department of Cardiology – name: 5 F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute |
Author_xml | – sequence: 1 givenname: Magali Noval surname: Rivas fullname: Rivas, Magali Noval organization: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA – sequence: 2 givenname: Joseph E surname: Ebinger fullname: Ebinger, Joseph E organization: Smidt Heart Institute – sequence: 3 givenname: Min surname: Wu fullname: Wu, Min organization: Smidt Heart Institute – sequence: 4 givenname: Nancy surname: Sun fullname: Sun, Nancy organization: Smidt Heart Institute – sequence: 5 givenname: Jonathan surname: Braun fullname: Braun, Jonathan organization: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute – sequence: 6 givenname: Kimia surname: Sobhani fullname: Sobhani, Kimia organization: Pathology and Laboratory Medicine – sequence: 7 givenname: Jennifer E surname: Van Eyk fullname: Van Eyk, Jennifer E organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA – sequence: 8 givenname: Susan surname: Cheng fullname: Cheng, Susan organization: Advanced Clinical Biosystems Institute, and – sequence: 9 givenname: Moshe surname: Arditi fullname: Arditi, Moshe organization: Smidt Heart Institute |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33211672$$D View this record in MEDLINE/PubMed |
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Snippet | BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to... BACKGROUND. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to... |
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Title | BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers |
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