Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse

• Published in: Thrombosis and haemostasis Vol. 99; no. 2; p. 435
• Main Authors: Tymvios, Charalambos, Jones, Sarah, Moore, Christopher, Pitchford, Simon C, Page, Clive P, Emerson, Michael
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2008
• Subjects: Adenosine Diphosphate - administration & dosage; Anesthesia; Animals; Aspirin - pharmacology; Aspirin - therapeutic use; Blood Platelets - drug effects; Collagen - administration & dosage; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes - drug effects; Hemodynamics - drug effects; Indium Radioisotopes; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxyquinoline - analogs & derivatives; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Platelet Count; Platelet Transfusion; Pulmonary Embolism - blood; Pulmonary Embolism - chemically induced; Pulmonary Embolism - drug therapy; Pulmonary Embolism - pathology; Pulmonary Embolism - physiopathology; Reproducibility of Results; Thrombin - administration & dosage; Thromboembolism - blood; Thromboembolism - chemically induced; Thromboembolism - drug therapy; Thromboembolism - pathology; Thromboembolism - physiopathology; Time Factors

Identifying and evaluating new therapeutic targets in platelets requires advanced animal models in which platelet responses can be measured directly and in situ. This is important because platelet function is strongly influenced by external factors such as those originating from the vascular endothe...