Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study

• Published in: Biological psychiatry (1969) Vol. 74; no. 6; pp. 458 - 466
• Main Authors: Khadka, Sabin, Meda, Shashwath A., Stevens, Michael C., Glahn, David C., Calhoun, Vince D., Sweeney, John A., Tamminga, Carol A., Keshavan, Matcheri S., O’Neil, Kasey, Schretlen, David, Pearlson, Godfrey D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2013
• Subjects: Adult; Bipolar; Bipolar Disorder - physiopathology; Brain - physiopathology; Brain Mapping; endophenotype; Endophenotypes; Female; Humans; Magnetic Resonance Imaging; Male; Nerve Net - physiopathology; Psychiatry; relatives; Rest - physiology; resting state; schizophrenia; Schizophrenia - physiopathology; within-network connectivity; endophenotype; Bipolar; resting state; schizophrenia; relatives; within-network connectivity

Schizophrenia and bipolar disorder share overlapping symptoms and risk genes. Shared aberrant functional connectivity is hypothesized in both disorders and in relatives. We investigated resting state functional magnetic resonance imaging in 70 schizophrenia and 64 psychotic bipolar probands, their r...