Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology - Piccoli, Luca; Park, Young-Jun; Tortorici, M. Alejandra; Czudnochowski, Nadine; Walls, Alexandra C.; Beltramello, Martina; Silacci-Fregni, Chiara; Pinto, Dora; Rosen, Laura E.; Bowen, John E.; Acton, Oliver J.; Jaconi, Stefano; et al. (Cell, 2020)
Keywords: Angiotensin-Converting Enzyme 2; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antigen-Antibody Reactions; BASIC BIOLOGICAL SCIENCES; Betacoronavirus - immunology; Betacoronavirus - isolation & purification; Betacoronavirus - metabolism; Binding Sites; Biochemistry, Molecular Biology; blood serum; Coronavirus Infections - pathology; Coronavirus Infections - virology; coronaviruses; COVID-19; COVID-19 infection; effector functions; Epitope Mapping - methods; Epitopes - chemistry; Epitopes - immunology; half life; Humans; immunity; Immunoglobulin A - blood; Immunoglobulin A - immunology; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M - blood; Immunoglobulin M - immunology; Kinetics; Life Sciences; Molecular Dynamics Simulation; neutralizing antibodies; nucleoproteins; Pandemics; Peptidyl-Dipeptidase A - chemistry; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Protein Binding; Protein Domains - immunology; Protein Structure, Quaternary; SARS-CoV-2; serology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; therapeutics; vaccine development; COVID-19; neutralizing antibodies; SARS-CoV-2; coronaviruses; immunity; effector functions