Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions

• Published in: Psychoneuroendocrinology Vol. 78; pp. 22 - 30
• Main Authors: Chen, Xu, Gautam, Pritam, Haroon, Ebrahim, Rilling, James K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2017
• Subjects: Administration, Intranasal; Adolescent; Brain - diagnostic imaging; Cooperative Behavior; Cross-Sectional Studies; Emotions - drug effects; Endocrinology & Metabolism; Female; Functional magnetic resonance imaging (fMRI); Humans; Interpersonal Relations; Magnetic Resonance Imaging; Male; Oxytocin; Oxytocin - administration & dosage; Prisoner Dilemma; Psychiatry; Social Behavior; Social cooperation; Ventral tegmental area (VTA); Within-subject design; Young Adult; Social cooperation; Functional magnetic resonance imaging (fMRI); Oxytocin; Within-subject design; Prisoner dilemma; Ventral tegmental area (VTA); functional magnetic resonance imaging (fMRI); Prisoner Dilemma

•First within-subject fMRI study to explore oxytocin effects on cooperation.•Oxytocin attenuates the VTA response to reciprocated cooperation in women.•Oxytocin prevents amygdala habituation to unreciprocated cooperation in men.•Results show some differences from previous cross-sectional studies. Th...