293-OR: Mitochondrial Hexokinase Dissociation Correlates with Obesity-Induced Inflammation and Regulates the Fate of Glucose

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. Supplement_1
• Main Authors: NEJAD, FARNAZ KEYHANI, DEJESUS, ADAM, GEIER, JUSTIN A., ARDEHALI, HOSSEIN
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2020
• Subjects: Body weight; Cell activation; Cytokines; Diabetes; Glucose; Glucose metabolism; Glucose tolerance; Glyceraldehyde-3-phosphate dehydrogenase; Glycolysis; Hexokinase; High fat diet; Immunological tolerance; Inflammation; Intermediates; Lipopolysaccharides; Localization; Metabolites; Metabolomics; Mitochondria; mRNA; Obesity; Phenotypes; Pyruvic acid; Spleen

It has been shown that high fat diet (HFD) induced obesity triggers local immune cell infiltration leading to pro-inflammatory cytokine production and subsequently to a state of chronic low-grade inflammation in adipose and spleen tissues. However, the underlying mechanisms driving this chronic infl...