1498-P: Preemptive Insulin Supplementation for Islet Graft Protection, Optimal Blood Glucose Control, and Fetal Development during the Pregnancy in Insulin-Independent Patient after Islet Transplantation

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: GONDEK, SARAH, OGLEDZINSKI, MATEUSZ, LIN, WILLIAM, MILEJCZYK, KAMILA, JUENGEL, BRADEN, POTTER, LISA, BACHUL, PIOTR J., BASTO, LINDSAY, PEREA, LAURENCIA, WANG, LINGJIA, TIBUDAN, MARTIN, BARTH, ROLF, FUNG, JOHN, WITKOWSKI, PIOTR
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Azathioprine; Blood glucose; Enterocolitis; Fetuses; Glucose; Hyperglycemia; Immunological tolerance; Insulin; Islet cells; Mycophenolic acid; Necrotizing enterocolitis; Neonates; Pancreas; Pancreatic islet transplantation; Pre-eclampsia; Pregnancy; Pregnancy complications; Supplements; Tacrolimus; Transplants & implants

Pregnancy increases metabolic demand for insulin, which may lead to the exhaustion of intraportally transplanted islets and postgestational hyperglycemia. Here we report a successful long-term preservation of islet graft function after two subsequent pregnancies while applying preemptive insulin sup...